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Biologically inactive leptin and early-onset extreme obesity.
Wabitsch M, Funcke JB, Lennerz B, Kuhnle-Krahl U, Lahr G, Debatin KM, Vatter P, Gierschik P, Moepps B, Fischer-Posovszky P. Wabitsch M, et al. Among authors: gierschik p. N Engl J Med. 2015 Jan 1;372(1):48-54. doi: 10.1056/NEJMoa1406653. N Engl J Med. 2015. PMID: 25551525 Free article.
A new missense mutation in the leptin gene causes mild obesity and hypogonadism without affecting T cell responsiveness.
Fischer-Posovszky P, von Schnurbein J, Moepps B, Lahr G, Strauss G, Barth TF, Kassubek J, Mühleder H, Möller P, Debatin KM, Gierschik P, Wabitsch M. Fischer-Posovszky P, et al. Among authors: gierschik p. J Clin Endocrinol Metab. 2010 Jun;95(6):2836-40. doi: 10.1210/jc.2009-2466. Epub 2010 Apr 9. J Clin Endocrinol Metab. 2010. PMID: 20382689
Severe Early-Onset Obesity Due to Bioinactive Leptin Caused by a p.N103K Mutation in the Leptin Gene.
Wabitsch M, Funcke JB, von Schnurbein J, Denzer F, Lahr G, Mazen I, El-Gammal M, Denzer C, Moss A, Debatin KM, Gierschik P, Mistry V, Keogh JM, Farooqi IS, Moepps B, Fischer-Posovszky P. Wabitsch M, et al. Among authors: gierschik p. J Clin Endocrinol Metab. 2015 Sep;100(9):3227-30. doi: 10.1210/jc.2015-2263. Epub 2015 Jul 17. J Clin Endocrinol Metab. 2015. PMID: 26186301 Free PMC article.
Measurement of immunofunctional leptin to detect and monitor patients with functional leptin deficiency.
Wabitsch M, Pridzun L, Ranke M, von Schnurbein J, Moss A, Brandt S, Kohlsdorf K, Moepps B, Schaab M, Funcke JB, Gierschik P, Fischer-Posovszky P, Flehmig B, Kratzsch J. Wabitsch M, et al. Among authors: gierschik p. Eur J Endocrinol. 2017 Mar;176(3):315-322. doi: 10.1530/EJE-16-0821. Epub 2016 Dec 22. Eur J Endocrinol. 2017. PMID: 28007844 Free PMC article.
Estimated prevalence of potentially damaging variants in the leptin gene.
Nunziata A, Borck G, Funcke JB, Kohlsdorf K, Brandt S, Hinney A, Moepps B, Gierschik P, Debatin KM, Fischer-Posovszky P, Wabitsch M. Nunziata A, et al. Among authors: gierschik p. Mol Cell Pediatr. 2017 Nov 3;4(1):10. doi: 10.1186/s40348-017-0074-x. Mol Cell Pediatr. 2017. PMID: 29101506 Free PMC article.
Functional and Phenotypic Characteristics of Human Leptin Receptor Mutations.
Nunziata A, Funcke JB, Borck G, von Schnurbein J, Brandt S, Lennerz B, Moepps B, Gierschik P, Fischer-Posovszky P, Wabitsch M. Nunziata A, et al. Among authors: gierschik p. J Endocr Soc. 2018 Sep 17;3(1):27-41. doi: 10.1210/js.2018-00123. eCollection 2019 Jan 1. J Endocr Soc. 2018. PMID: 30560226 Free PMC article. Review.
Absence of CC chemokine receptors 2a and 2b from human adipose lineage cells.
Koenig C, Fischer-Posovszky P, Rojewski MT, Tews D, Schrezenmeier H, Wabitsch M, Gierschik P, Moepps B. Koenig C, et al. Among authors: gierschik p. Mol Cell Endocrinol. 2013 Apr 30;369(1-2):72-85. doi: 10.1016/j.mce.2013.01.008. Epub 2013 Jan 29. Mol Cell Endocrinol. 2013. PMID: 23376609
Compound heterozygous variants in OTULIN are associated with fulminant atypical late-onset ORAS.
Zinngrebe J, Moepps B, Monecke T, Gierschik P, Schlichtig F, Barth TFE, Strauß G, Boldrin E, Posovszky C, Schulz A, Beringer O, Rieser E, Jacobsen EM, Lorenz MR, Schwarz K, Pannicke U, Walczak H, Niessing D, Schuetz C, Fischer-Posovszky P, Debatin KM. Zinngrebe J, et al. Among authors: gierschik p. EMBO Mol Med. 2022 Mar 7;14(3):e14901. doi: 10.15252/emmm.202114901. Epub 2022 Feb 16. EMBO Mol Med. 2022. PMID: 35170849 Free PMC article.
177 results