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Fatty acid desaturation by stearoyl-CoA desaturase-1 controls regulatory T cell differentiation and autoimmunity.
Grajchen E, Loix M, Baeten P, Côrte-Real BF, Hamad I, Vanherle S, Haidar M, Dehairs J, Broos JY, Ntambi JM, Zimmermann R, Breinbauer R, Stinissen P, Hellings N, Verberk SGS, Kooij G, Giera M, Swinnen JV, Broux B, Kleinewietfeld M, Hendriks JJA, Bogie JFJ. Grajchen E, et al. Among authors: giera m. Cell Mol Immunol. 2023 Jun;20(6):666-679. doi: 10.1038/s41423-023-01011-2. Epub 2023 Apr 12. Cell Mol Immunol. 2023. PMID: 37041314 Free PMC article.
Association of Arachidonic Acid-Derived Lipid Mediators With Disease Severity in Patients With Relapsing and Progressive Multiple Sclerosis.
Broos JY, Loonstra FC, de Ruiter LRJ, Gouda M, Fung WH, Schoonheim MM, Heijink M, Strijbis EMM, Teunissen C, Killestein J, de Vries HE, Giera M, Uitdehaag BMJ, Kooij G. Broos JY, et al. Among authors: giera m. Neurology. 2023 Aug 1;101(5):e533-e545. doi: 10.1212/WNL.0000000000207459. Epub 2023 Jun 8. Neurology. 2023. PMID: 37290971 Free PMC article.
The whipworm (Trichuris suis) secretes prostaglandin E2 to suppress proinflammatory properties in human dendritic cells.
Laan LC, Williams AR, Stavenhagen K, Giera M, Kooij G, Vlasakov I, Kalay H, Kringel H, Nejsum P, Thamsborg SM, Wuhrer M, Dijkstra CD, Cummings RD, van Die I. Laan LC, et al. Among authors: giera m. FASEB J. 2017 Feb;31(2):719-731. doi: 10.1096/fj.201600841R. Epub 2016 Nov 2. FASEB J. 2017. PMID: 27806992 Free PMC article.
We conclude that T. suis secretes PGE2 to suppress proinflammatory responses in human DCs, thereby modulating the host's immune response.-Laan, L. C., Williams, A. R., Stavenhagen, K., Giera, M., Kooij, G., Vlasakov, I., Kalay, H., Kringel, H., Nejsum, P., Thamsborg …
We conclude that T. suis secretes PGE2 to suppress proinflammatory responses in human DCs, thereby modulating the host's immune response.-La …
Cold exposure induces dynamic changes in circulating triacylglycerol species, which is dependent on intracellular lipolysis: A randomized cross-over trial.
Straat ME, Jurado-Fasoli L, Ying Z, Nahon KJ, Janssen LGM, Boon MR, Grabner GF, Kooijman S, Zimmermann R, Giera M, Rensen PCN, Martinez-Tellez B. Straat ME, et al. Among authors: giera m. EBioMedicine. 2022 Dec;86:104349. doi: 10.1016/j.ebiom.2022.104349. Epub 2022 Nov 11. EBioMedicine. 2022. PMID: 36371986 Free PMC article. Clinical Trial.
Fasciola hepatica Fatty Acid Binding Protein 1 Modulates T cell Polarization by Promoting Dendritic Cell Thrombospondin-1 Secretion Without Affecting Metabolic Homeostasis in Obese Mice.
Zawistowska-Deniziak A, Lambooij JM, Kalinowska A, Patente TA, Łapiński M, van der Zande HJP, Basałaj K, de Korne CM, Chayé MAM, Gasan TA, Norbury LJ, Giera M, Zaldumbide A, Smits HH, Guigas B. Zawistowska-Deniziak A, et al. Among authors: giera m. Front Immunol. 2022 May 26;13:884663. doi: 10.3389/fimmu.2022.884663. eCollection 2022. Front Immunol. 2022. PMID: 35720355 Free PMC article.
Spatial dynamic metabolomics identifies metabolic cell fate trajectories in human kidney differentiation.
Wang G, Heijs B, Kostidis S, Rietjens RGJ, Koning M, Yuan L, Tiemeier GL, Mahfouz A, Dumas SJ, Giera M, Kers J, Chuva de Sousa Lopes SM, van den Berg CW, van den Berg BM, Rabelink TJ. Wang G, et al. Among authors: giera m. Cell Stem Cell. 2022 Nov 3;29(11):1580-1593.e7. doi: 10.1016/j.stem.2022.10.008. Cell Stem Cell. 2022. PMID: 36332571 Free article.
Fatty acid desaturation and lipoxygenase pathways support trained immunity.
Ferreira AV, Alarcon-Barrera JC, Domínguez-Andrés J, Bulut Ö, Kilic G, Debisarun PA, Röring RJ, Özhan HN, Terschlüsen E, Ziogas A, Kostidis S, Mohammed Y, Matzaraki V, Renieris G, Giamarellos-Bourboulis EJ, Netea MG, Giera M. Ferreira AV, et al. Among authors: giera m. Nat Commun. 2023 Nov 15;14(1):7385. doi: 10.1038/s41467-023-43315-x. Nat Commun. 2023. PMID: 37968313 Free PMC article.
192 results