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Integrative analysis of loss-of-function variants in clinical and genomic data reveals novel genes associated with cardiovascular traits.
Glicksberg BS, Amadori L, Akers NK, Sukhavasi K, Franzén O, Li L, Belbin GM, Ayers KL, Shameer K, Badgeley MA, Johnson KW, Readhead B, Darrow BJ, Kenny EE, Betsholtz C, Ermel R, Skogsberg J, Ruusalepp A, Schadt EE, Dudley JT, Ren H, Kovacic JC, Giannarelli C, Li SD, Björkegren JLM, Chen R. Glicksberg BS, et al. Among authors: giannarelli c. BMC Med Genomics. 2019 Jul 25;12(Suppl 6):108. doi: 10.1186/s12920-019-0542-3. BMC Med Genomics. 2019. PMID: 31345219 Free PMC article.
Alternatively spliced tissue factor promotes plaque angiogenesis through the activation of hypoxia-inducible factor-1α and vascular endothelial growth factor signaling.
Giannarelli C, Alique M, Rodriguez DT, Yang DK, Jeong D, Calcagno C, Hutter R, Millon A, Kovacic JC, Weber T, Faries PL, Soff GA, Fayad ZA, Hajjar RJ, Fuster V, Badimon JJ. Giannarelli C, et al. Circulation. 2014 Oct 7;130(15):1274-86. doi: 10.1161/CIRCULATIONAHA.114.006614. Epub 2014 Aug 12. Circulation. 2014. PMID: 25116956 Free PMC article.
Cross-Tissue Regulatory Gene Networks in Coronary Artery Disease.
Talukdar HA, Foroughi Asl H, Jain RK, Ermel R, Ruusalepp A, Franzén O, Kidd BA, Readhead B, Giannarelli C, Kovacic JC, Ivert T, Dudley JT, Civelek M, Lusis AJ, Schadt EE, Skogsberg J, Michoel T, Björkegren JL. Talukdar HA, et al. Among authors: giannarelli c. Cell Syst. 2016 Mar 23;2(3):196-208. doi: 10.1016/j.cels.2016.02.002. Epub 2016 Mar 3. Cell Syst. 2016. PMID: 27135365 Free PMC article.
Cardiometabolic risk loci share downstream cis- and trans-gene regulation across tissues and diseases.
Franzén O, Ermel R, Cohain A, Akers NK, Di Narzo A, Talukdar HA, Foroughi-Asl H, Giambartolomei C, Fullard JF, Sukhavasi K, Köks S, Gan LM, Giannarelli C, Kovacic JC, Betsholtz C, Losic B, Michoel T, Hao K, Roussos P, Skogsberg J, Ruusalepp A, Schadt EE, Björkegren JL. Franzén O, et al. Among authors: giannarelli c. Science. 2016 Aug 19;353(6301):827-30. doi: 10.1126/science.aad6970. Science. 2016. PMID: 27540175 Free PMC article.
Rationale and Design of Family-Based Approach in a Minority Community Integrating Systems-Biology for Promotion of Health (FAMILIA).
Bansilal S, Vedanthan R, Kovacic JC, Soto AV, Latina J, Björkegren JLM, Jaslow R, Santana M, Sartori S, Giannarelli C, Mani V, Hajjar R, Schadt E, Kasarskis A, Fayad ZA, Fuster V. Bansilal S, et al. Among authors: giannarelli c. Am Heart J. 2017 May;187:170-181. doi: 10.1016/j.ahj.2017.02.020. Epub 2017 Feb 22. Am Heart J. 2017. PMID: 28454800 Free PMC article. Clinical Trial.
Global analysis of A-to-I RNA editing reveals association with common disease variants.
Franzén O, Ermel R, Sukhavasi K, Jain R, Jain A, Betsholtz C, Giannarelli C, Kovacic JC, Ruusalepp A, Skogsberg J, Hao K, Schadt EE, Björkegren JLM. Franzén O, et al. Among authors: giannarelli c. PeerJ. 2018 Mar 6;6:e4466. doi: 10.7717/peerj.4466. eCollection 2018. PeerJ. 2018. PMID: 29527417 Free PMC article.
Systems Pharmacology Identifies an Arterial Wall Regulatory Gene Network Mediating Coronary Artery Disease Side Effects of Antiretroviral Therapy.
Frades I, Readhead B, Amadori L, Koplev S, Talukdar HA, Crane HM, Crane PK, Kovacic JC, Dudley JT, Giannarelli C, Björkegren JLM, Peter I. Frades I, et al. Among authors: giannarelli c. Circ Genom Precis Med. 2019 Jun;12(6):e002390. doi: 10.1161/CIRCGEN.118.002390. Epub 2019 May 6. Circ Genom Precis Med. 2019. PMID: 31059280 Free PMC article.
Contribution of Gene Regulatory Networks to Heritability of Coronary Artery Disease.
Zeng L, Talukdar HA, Koplev S, Giannarelli C, Ivert T, Gan LM, Ruusalepp A, Schadt EE, Kovacic JC, Lusis AJ, Michoel T, Schunkert H, Björkegren JLM. Zeng L, et al. Among authors: giannarelli c. J Am Coll Cardiol. 2019 Jun 18;73(23):2946-2957. doi: 10.1016/j.jacc.2019.03.520. J Am Coll Cardiol. 2019. PMID: 31196451 Free PMC article.
Single-cell immune landscape of human atherosclerotic plaques.
Fernandez DM, Rahman AH, Fernandez NF, Chudnovskiy A, Amir ED, Amadori L, Khan NS, Wong CK, Shamailova R, Hill CA, Wang Z, Remark R, Li JR, Pina C, Faries C, Awad AJ, Moss N, Bjorkegren JLM, Kim-Schulze S, Gnjatic S, Ma'ayan A, Mocco J, Faries P, Merad M, Giannarelli C. Fernandez DM, et al. Among authors: giannarelli c. Nat Med. 2019 Oct;25(10):1576-1588. doi: 10.1038/s41591-019-0590-4. Epub 2019 Oct 7. Nat Med. 2019. PMID: 31591603 Free PMC article.
87 results