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Engineered peptide PLG0206 overcomes limitations of a challenging antimicrobial drug class.
Huang DB, Brothers KM, Mandell JB, Taguchi M, Alexander PG, Parker DM, Shinabarger D, Pillar C, Morrissey I, Hawser S, Ghahramani P, Dobbins D, Pachuda N, Montelaro R, Steckbeck JD, Urish KL. Huang DB, et al. Among authors: ghahramani p. PLoS One. 2022 Sep 16;17(9):e0274815. doi: 10.1371/journal.pone.0274815. eCollection 2022. PLoS One. 2022. PMID: 36112657 Free PMC article.
A Phase 1 Study of the Safety, Tolerability, and Pharmacokinetics of Single Ascending Doses of a First-in-Human Engineered Cationic Peptide, PLG0206, Intravenously Administered in Healthy Subjects.
Huang D, Dobbins D, Ghahramani P, Friedland I, Steckbeck J. Huang D, et al. Among authors: ghahramani p. Antimicrob Agents Chemother. 2022 Jan 18;66(1):e0144121. doi: 10.1128/AAC.01441-21. Epub 2021 Nov 22. Antimicrob Agents Chemother. 2022. PMID: 34807760 Free PMC article. Clinical Trial.
35 results