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A "spindle and thread" mechanism unblocks p53 translation by modulating N-terminal disorder.
Kaldmäe M, Vosselman T, Zhong X, Lama D, Chen G, Saluri M, Kronqvist N, Siau JW, Ng AS, Ghadessy FJ, Sabatier P, Vojtesek B, Sarr M, Sahin C, Österlund N, Ilag LL, Väänänen VA, Sedimbi S, Arsenian-Henriksson M, Zubarev RA, Nilsson L, Koeck PJB, Rising A, Abelein A, Fritz N, Johansson J, Lane DP, Landreh M. Kaldmäe M, et al. Among authors: ghadessy fj. Structure. 2022 May 5;30(5):733-742.e7. doi: 10.1016/j.str.2022.02.013. Epub 2022 Mar 14. Structure. 2022. PMID: 35290795 Free article.
Mdm2 and p53 are highly conserved from placozoans to man.
Lane DP, Cheok CF, Brown C, Madhumalar A, Ghadessy FJ, Verma C. Lane DP, et al. Among authors: ghadessy fj. Cell Cycle. 2010 Feb 1;9(3):540-7. doi: 10.4161/cc.9.3.10516. Cell Cycle. 2010. PMID: 20081368
The Mdm2 and p53 genes are conserved in the Arachnids.
Lane DP, Cheok CF, Brown CJ, Madhumalar A, Ghadessy FJ, Verma C. Lane DP, et al. Among authors: ghadessy fj. Cell Cycle. 2010 Feb 15;9(4):748-54. doi: 10.4161/cc.9.4.10616. Epub 2010 Feb 12. Cell Cycle. 2010. PMID: 20160485
Inhibition of nutlin-resistant HDM2 mutants by stapled peptides.
Wei SJ, Joseph T, Chee S, Li L, Yurlova L, Zolghadr K, Brown C, Lane D, Verma C, Ghadessy F. Wei SJ, et al. PLoS One. 2013 Nov 20;8(11):e81068. doi: 10.1371/journal.pone.0081068. eCollection 2013. PLoS One. 2013. PMID: 24278380 Free PMC article.
64 results