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The discovery of novel and potent indazole NLRP3 inhibitors enabled by DNA-encoded library screening.
Hartman G, Humphries P, Hughes R, Ho A, Montgomery R, Deshpande A, Mahanta M, Tronnes S, Cowdin S, He X, Liu F, Zhang L, Liu C, Dou D, Li J, Spasic A, Coll R, Marleaux M, Hochheiser IV, Geyer M, Rubin P, Fortney K, Wilhelmsen K. Hartman G, et al. Among authors: geyer m. Bioorg Med Chem Lett. 2024 Apr 1;102:129675. doi: 10.1016/j.bmcl.2024.129675. Epub 2024 Feb 28. Bioorg Med Chem Lett. 2024. PMID: 38417632
A conserved isoleucine in the binding pocket of RIG-I controls immune tolerance to mitochondrial RNA.
de Regt AK, Anand K, Ciupka K, Bender F, Gatterdam K, Putschli B, Fusshöller D, Hilbig D, Kirchhoff A, Hunkler C, Wolter S, Grünewald A, Wallerath C, Schuberth-Wagner C, Ludwig J, Paeschke K, Bartok E, Hagelueken G, Hartmann G, Zillinger T, Geyer M, Schlee M. de Regt AK, et al. Among authors: geyer m. Nucleic Acids Res. 2023 Nov 27;51(21):11893-11910. doi: 10.1093/nar/gkad835. Nucleic Acids Res. 2023. PMID: 37831086 Free PMC article.
Atrial arrhythmias following CAR-chimeric antigen receptor T-cell therapy: Incidence, risk factors and biomarker profile.
Shouval R, Goldman A, Flynn JR, El-Moghraby A, Rehman M, Devlin SM, Corona M, Landego I, Lin RJ, Scordo M, Raj SS, Giralt SA, Palomba ML, Dahi PB, Walji M, Salles G, Nath K, Geyer MB, Park JH, Fein JA, Kosmidou I, Shah GL, Liu JE, Perales MA, Mahmood SS. Shouval R, et al. Among authors: geyer mb. Br J Haematol. 2024 May 12. doi: 10.1111/bjh.19497. Online ahead of print. Br J Haematol. 2024. PMID: 38735683
Universal germline genetic testing in patients with hematologic malignancies using DNA isolated from nail clippings.
Ceyhan-Birsoy O, Fiala E, Rana S, Sheehan M, Kennedy J, Yelskaya Z, Rai V, Li Y, Yang C, Wong D, Rijo I, Casanova J, Somar J, Mehta N, Park H, Ostafi S, Arora K, Padunan A, Ewalt MD, Aypar U, Terraf P, Misyura M, Haque S, Behr GG, Haque T, Sulis M, Geyer MB, Forlenza C, Thompson MC, Carlo M, Latham A, Liu Y, Zehir A, Brannon R, Berger M, Diaz LA Jr, Dogan A, Ladanyi M, Petrova-Drus K, Nafa K, Offit K, Arcila M, Stadler ZK, Walsh MF, Mandelker D. Ceyhan-Birsoy O, et al. Among authors: geyer mb. Haematologica. 2024 Apr 4. doi: 10.3324/haematol.2024.285055. Online ahead of print. Haematologica. 2024. PMID: 38572560 Free article.
1,085 results