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The RacGAP ArhGAP15 is a master negative regulator of neutrophil functions.
Costa C, Germena G, Martin-Conte EL, Molineris I, Bosco E, Marengo S, Azzolino O, Altruda F, Ranieri VM, Hirsch E. Costa C, et al. Among authors: germena g. Blood. 2011 Jul 28;118(4):1099-108. doi: 10.1182/blood-2010-12-324756. Epub 2011 May 6. Blood. 2011. PMID: 21551229 Free article.
PI3K keeps the balance between metabolism and cancer.
Braccini L, Ciraolo E, Martini M, Pirali T, Germena G, Rolfo K, Hirsch E. Braccini L, et al. Among authors: germena g. Adv Biol Regul. 2012 Sep;52(3):389-405. doi: 10.1016/j.jbior.2012.04.002. Epub 2012 Apr 24. Adv Biol Regul. 2012. PMID: 22884032 Review.
PI3K class II α controls spatially restricted endosomal PtdIns3P and Rab11 activation to promote primary cilium function.
Franco I, Gulluni F, Campa CC, Costa C, Margaria JP, Ciraolo E, Martini M, Monteyne D, De Luca E, Germena G, Posor Y, Maffucci T, Marengo S, Haucke V, Falasca M, Perez-Morga D, Boletta A, Merlo GR, Hirsch E. Franco I, et al. Among authors: germena g. Dev Cell. 2014 Mar 31;28(6):647-58. doi: 10.1016/j.devcel.2014.01.022. Dev Cell. 2014. PMID: 24697898 Free PMC article.
Crossroads of PI3K and Rac pathways.
Campa CC, Ciraolo E, Ghigo A, Germena G, Hirsch E. Campa CC, et al. Among authors: germena g. Small GTPases. 2015;6(2):71-80. doi: 10.4161/21541248.2014.989789. Epub 2015 May 5. Small GTPases. 2015. PMID: 25942647 Free PMC article. Review.
Disruption of ArhGAP15 results in hyperactive Rac1, affects the architecture and function of hippocampal inhibitory neurons and causes cognitive deficits.
Zamboni V, Armentano M, Sarò G, Ciraolo E, Ghigo A, Germena G, Umbach A, Valnegri P, Passafaro M, Carabelli V, Gavello D, Bianchi V, D'Adamo P, de Curtis I, El-Assawi N, Mauro A, Priano L, Ferri N, Hirsch E, Merlo GR. Zamboni V, et al. Among authors: germena g. Sci Rep. 2016 Oct 7;6:34877. doi: 10.1038/srep34877. Sci Rep. 2016. PMID: 27713499 Free PMC article.
Rac signal adaptation controls neutrophil mobilization from the bone marrow.
Campa CC, Germena G, Ciraolo E, Copperi F, Sapienza A, Franco I, Ghigo A, Camporeale A, Di Savino A, Martini M, Perino A, Megens RT, Kurz AR, Scheiermann C, Sperandio M, Gamba A, Hirsch E. Campa CC, et al. Among authors: germena g. Sci Signal. 2016 Dec 20;9(459):ra124. doi: 10.1126/scisignal.aah5882. Sci Signal. 2016. PMID: 27999173
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