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Proof-of-concept that network pharmacology is effective to modify development of acquired temporal lobe epilepsy.
Schidlitzki A, Bascuñana P, Srivastava PK, Welzel L, Twele F, Töllner K, Käufer C, Gericke B, Feleke R, Meier M, Polyak A, Ross TL, Gerhauser I, Bankstahl JP, Johnson MR, Bankstahl M, Löscher W. Schidlitzki A, et al. Among authors: gericke b. Neurobiol Dis. 2020 Feb;134:104664. doi: 10.1016/j.nbd.2019.104664. Epub 2019 Nov 1. Neurobiol Dis. 2020. PMID: 31678583 Free article.
Novel brain permeant mTORC1/2 inhibitors are as efficacious as rapamycin or everolimus in mouse models of acquired partial epilepsy and tuberous sclerosis complex.
Theilmann W, Gericke B, Schidlitzki A, Muneeb Anjum SM, Borsdorf S, Harries T, Roberds SL, Aguiar DJ, Brunner D, Leiser SC, Song D, Fabbro D, Hillmann P, Wymann MP, Löscher W. Theilmann W, et al. Among authors: gericke b. Neuropharmacology. 2020 Dec 1;180:108297. doi: 10.1016/j.neuropharm.2020.108297. Epub 2020 Sep 3. Neuropharmacology. 2020. PMID: 32890589
Deletion of the Na-K-2Cl cotransporter NKCC1 results in a more severe epileptic phenotype in the intrahippocampal kainate mouse model of temporal lobe epilepsy.
Hampel P, Johne M, Gailus B, Vogel A, Schidlitzki A, Gericke B, Töllner K, Theilmann W, Käufer C, Römermann K, Kaila K, Löscher W. Hampel P, et al. Among authors: gericke b. Neurobiol Dis. 2021 May;152:105297. doi: 10.1016/j.nbd.2021.105297. Epub 2021 Feb 11. Neurobiol Dis. 2021. PMID: 33581254 Free article.
46 results