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A natural product inspired tetrahydropyran collection yields mitosis modulators that synergistically target CSE1L and tubulin.
Angew Chem Int Ed Engl. 2013 Jan 2;52(1):410-4. doi: 10.1002/anie.201205728. Epub 2012 Oct 18.
Angew Chem Int Ed Engl. 2013.
PMID: 23080551
Podoverine A--a novel microtubule destabilizing natural product from the Podophyllum species.
Tran TT, Gerding-Reimers C, Schölermann B, Stanitzki B, Henkel T, Waldmann H, Ziegler S.
Tran TT, et al. Among authors: gerding reimers c.
Bioorg Med Chem. 2014 Sep 15;22(18):5110-6. doi: 10.1016/j.bmc.2014.01.039. Epub 2014 Feb 1.
Bioorg Med Chem. 2014.
PMID: 24530033
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Highly enantioselective synthesis and cellular evaluation of spirooxindoles inspired by natural products.
Antonchick AP, Gerding-Reimers C, Catarinella M, Schürmann M, Preut H, Ziegler S, Rauh D, Waldmann H.
Antonchick AP, et al. Among authors: gerding reimers c.
Nat Chem. 2010 Sep;2(9):735-40. doi: 10.1038/nchem.730. Epub 2010 Jul 11.
Nat Chem. 2010.
PMID: 20729892
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Development of highly potent inhibitors of the Ras-targeting human acyl protein thioesterases based on substrate similarity design.
Hedberg C, Dekker FJ, Rusch M, Renner S, Wetzel S, Vartak N, Gerding-Reimers C, Bon RS, Bastiaens PI, Waldmann H.
Hedberg C, et al. Among authors: gerding reimers c.
Angew Chem Int Ed Engl. 2011 Oct 10;50(42):9832-7. doi: 10.1002/anie.201102965. Epub 2011 Sep 9.
Angew Chem Int Ed Engl. 2011.
PMID: 21905185
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Prieurianin/endosidin 1 is an actin-stabilizing small molecule identified from a chemical genetic screen for circadian clock effectors in Arabidopsis thaliana.
Tóth R, Gerding-Reimers C, Deeks MJ, Menninger S, Gallegos RM, Tonaco IA, Hübel K, Hussey PJ, Waldmann H, Coupland G.
Tóth R, et al. Among authors: gerding reimers c.
Plant J. 2012 Jul;71(2):338-52. doi: 10.1111/j.1365-313X.2012.04991.x. Epub 2012 Jun 28.
Plant J. 2012.
PMID: 22409627
Free article.
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Anatomy and dynamics of a supramolecular membrane protein cluster.
Sieber JJ, Willig KI, Kutzner C, Gerding-Reimers C, Harke B, Donnert G, Rammner B, Eggeling C, Hell SW, Grubmüller H, Lang T.
Sieber JJ, et al. Among authors: gerding reimers c.
Science. 2007 Aug 24;317(5841):1072-6. doi: 10.1126/science.1141727.
Science. 2007.
PMID: 17717182
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