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Orally-active, clinically-translatable senolytics restore α-Klotho in mice and humans.
Zhu Y, Prata LGPL, Gerdes EOW, Netto JME, Pirtskhalava T, Giorgadze N, Tripathi U, Inman CL, Johnson KO, Xue A, Palmer AK, Chen T, Schaefer K, Justice JN, Nambiar AM, Musi N, Kritchevsky SB, Chen J, Khosla S, Jurk D, Schafer MJ, Tchkonia T, Kirkland JL. Zhu Y, et al. Among authors: gerdes eow. EBioMedicine. 2022 Mar;77:103912. doi: 10.1016/j.ebiom.2022.103912. Epub 2022 Mar 13. EBioMedicine. 2022. PMID: 35292270 Free PMC article.
SARS-CoV-2 causes senescence in human cells and exacerbates the senescence-associated secretory phenotype through TLR-3.
Tripathi U, Nchioua R, Prata LGPL, Zhu Y, Gerdes EOW, Giorgadze N, Pirtskhalava T, Parker E, Xue A, Espindola-Netto JM, Stenger S, Robbins PD, Niedernhofer LJ, Dickinson SL, Allison DB, Kirchhoff F, Sparrer KMJ, Tchkonia T, Kirkland JL. Tripathi U, et al. Among authors: gerdes eow. Aging (Albany NY). 2021 Sep 16;13(18):21838-21854. doi: 10.18632/aging.203560. Epub 2021 Sep 16. Aging (Albany NY). 2021. PMID: 34531331 Free PMC article.
Community paramedic hospital reduction and mitigation program: study protocol for a randomized pragmatic clinical trial.
Ridgeway JL, Gerdes EOW, Dodge A, Liedl CP, Juntunen MB, Sundt WJS, Glasgow A, Lampman MA, Fink AL, Severson SB, Lin G, Sampson RR, Peterson RP, Murley BM, Klassen AB, Luke A, Friedman PA, Buechler TE, Newman JS, McCoy RG. Ridgeway JL, et al. Among authors: gerdes eow. Trials. 2023 Feb 20;24(1):122. doi: 10.1186/s13063-022-07034-w. Trials. 2023. PMID: 36805692 Free PMC article.