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Broadly neutralizing antibodies target the coronavirus fusion peptide.
Dacon C, Tucker C, Peng L, Lee CD, Lin TH, Yuan M, Cong Y, Wang L, Purser L, Williams JK, Pyo CW, Kosik I, Hu Z, Zhao M, Mohan D, Cooper AJR, Peterson M, Skinner J, Dixit S, Kollins E, Huzella L, Perry D, Byrum R, Lembirik S, Drawbaugh D, Eaton B, Zhang Y, Yang ES, Chen M, Leung K, Weinberg RS, Pegu A, Geraghty DE, Davidson E, Douagi I, Moir S, Yewdell JW, Schmaljohn C, Crompton PD, Holbrook MR, Nemazee D, Mascola JR, Wilson IA, Tan J. Dacon C, et al. Among authors: geraghty de. Science. 2022 Aug 12;377(6607):728-735. doi: 10.1126/science.abq3773. Epub 2022 Jul 12. Science. 2022. PMID: 35857439 Free PMC article.
Antibody Fc effector functions and IgG3 associate with decreased HIV-1 risk.
Neidich SD, Fong Y, Li SS, Geraghty DE, Williamson BD, Young WC, Goodman D, Seaton KE, Shen X, Sawant S, Zhang L, deCamp AC, Blette BS, Shao M, Yates NL, Feely F, Pyo CW, Ferrari G; HVTN 505 Team; Frank I, Karuna ST, Swann EM, Mascola JR, Graham BS, Hammer SM, Sobieszczyk ME, Corey L, Janes HE, McElrath MJ, Gottardo R, Gilbert PB, Tomaras GD. Neidich SD, et al. Among authors: geraghty de. J Clin Invest. 2019 Nov 1;129(11):4838-4849. doi: 10.1172/JCI126391. J Clin Invest. 2019. PMID: 31589165 Free PMC article. Clinical Trial.
Mutations in viral nucleocapsid protein and endoRNase are discovered to associate with COVID19 hospitalization risk.
Zhao LP, Roychoudhury P, Gilbert P, Schiffer J, Lybrand TP, Payne TH, Randhawa A, Thiebaud S, Mills M, Greninger A, Pyo CW, Wang R, Li R, Thomas A, Norris B, Nelson WC, Jerome KR, Geraghty DE. Zhao LP, et al. Among authors: geraghty de. Sci Rep. 2022 Jan 24;12(1):1206. doi: 10.1038/s41598-021-04376-4. Sci Rep. 2022. PMID: 35075180 Free PMC article.
177 results