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Assessing developability early in the discovery process for novel biologics.
Fernández-Quintero ML, Ljungars A, Waibl F, Greiff V, Andersen JT, Gjølberg TT, Jenkins TP, Voldborg BG, Grav LM, Kumar S, Georges G, Kettenberger H, Liedl KR, Tessier PM, McCafferty J, Laustsen AH. Fernández-Quintero ML, et al. Among authors: georges g. MAbs. 2023 Jan-Dec;15(1):2171248. doi: 10.1080/19420862.2023.2171248. MAbs. 2023. PMID: 36823021 Free PMC article. Review.
Immunoglobulin domain crossover as a generic approach for the production of bispecific IgG antibodies.
Schaefer W, Regula JT, Bähner M, Schanzer J, Croasdale R, Dürr H, Gassner C, Georges G, Kettenberger H, Imhof-Jung S, Schwaiger M, Stubenrauch KG, Sustmann C, Thomas M, Scheuer W, Klein C. Schaefer W, et al. Among authors: georges g. Proc Natl Acad Sci U S A. 2011 Jul 5;108(27):11187-92. doi: 10.1073/pnas.1019002108. Epub 2011 Jun 20. Proc Natl Acad Sci U S A. 2011. PMID: 21690412 Free PMC article.
Response to: monoclonal antibodies targeting CD20.
Klein C, Lammens A, Schäfer W, Georges G, Schwaiger M, Mössner E, Hopfner KP, Umaña P, Niederfellner G. Klein C, et al. Among authors: georges g. MAbs. 2013 May-Jun;5(3):337-8. doi: 10.4161/mabs.24108. Epub 2013 Mar 14. MAbs. 2013. PMID: 23493087 Free PMC article. No abstract available.
MoFvAb: Modeling the Fv region of antibodies.
Bujotzek A, Fuchs A, Qu C, Benz J, Klostermann S, Antes I, Georges G. Bujotzek A, et al. Among authors: georges g. MAbs. 2015;7(5):838-52. doi: 10.1080/19420862.2015.1068492. MAbs. 2015. PMID: 26176812 Free PMC article.
VH -VL interdomain dynamics observed by computer simulations and NMR.
Fernández-Quintero ML, Hoerschinger VJ, Lamp LM, Bujotzek A, Georges G, Liedl KR. Fernández-Quintero ML, et al. Among authors: georges g. Proteins. 2020 Jul;88(7):830-839. doi: 10.1002/prot.25872. Epub 2020 Jan 14. Proteins. 2020. PMID: 31904133 Free PMC article.
Conformational Ensembles of Antibodies Determine Their Hydrophobicity.
Waibl F, Fernández-Quintero ML, Kamenik AS, Kraml J, Hofer F, Kettenberger H, Georges G, Liedl KR. Waibl F, et al. Among authors: georges g. Biophys J. 2021 Jan 5;120(1):143-157. doi: 10.1016/j.bpj.2020.11.010. Epub 2020 Nov 18. Biophys J. 2021. PMID: 33220303 Free PMC article.
276 results