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Tissue pharmacokinetics of antisense oligonucleotides.
Bäckström E, Bonetti A, Johnsson P, Öhlin S, Dahlén A, Andersson P, Andersson S, Gennemark P. Bäckström E, et al. Among authors: gennemark p. Mol Ther Nucleic Acids. 2024 Feb 2;35(1):102133. doi: 10.1016/j.omtn.2024.102133. eCollection 2024 Mar 12. Mol Ther Nucleic Acids. 2024. PMID: 38419941 Free PMC article.
An oral antisense oligonucleotide for PCSK9 inhibition.
Gennemark P, Walter K, Clemmensen N, Rekić D, Nilsson CAM, Knöchel J, Hölttä M, Wernevik L, Rosengren B, Kakol-Palm D, Wang Y, Yu RZ, Geary RS, Riney SJ, Monia BP, Isaksson R, Jansson-Löfmark R, Rocha CSJ, Lindén D, Hurt-Camejo E, Crooke R, Tillman L, Rydén-Bergsten T, Carlsson B, Andersson U, Elebring M, Tivesten A, Davies N. Gennemark P, et al. Sci Transl Med. 2021 May 12;13(593):eabe9117. doi: 10.1126/scitranslmed.abe9117. Sci Transl Med. 2021. PMID: 33980578
Integrated experimental-computational analysis of a HepaRG liver-islet microphysiological system for human-centric diabetes research.
Casas B, Vilén L, Bauer S, Kanebratt KP, Wennberg Huldt C, Magnusson L, Marx U, Andersson TB, Gennemark P, Cedersund G. Casas B, et al. Among authors: gennemark p. PLoS Comput Biol. 2022 Oct 19;18(10):e1010587. doi: 10.1371/journal.pcbi.1010587. eCollection 2022 Oct. PLoS Comput Biol. 2022. PMID: 36260620 Free PMC article.
A case-study of model-informed drug development of a novel PCSK9 anti sense oligonucleotide. Part 1: First time in man to phase II.
Knöchel J, Nilsson C, Carlsson B, Wernevik L, Hofherr A, Gennemark P, Jansson-Löfmark R, Isaksson R, Rydén-Bergsten T, Hamrén B, Rekić D. Knöchel J, et al. Among authors: gennemark p. CPT Pharmacometrics Syst Pharmacol. 2022 Dec;11(12):1569-1577. doi: 10.1002/psp4.12866. Epub 2022 Oct 1. CPT Pharmacometrics Syst Pharmacol. 2022. PMID: 36126230 Free PMC article. Clinical Trial.
48 results