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Genome-wide CRISPR activation screening in senescent cells reveals SOX5 as a driver and therapeutic target of rejuvenation.
Jing Y, Jiang X, Ji Q, Wu Z, Wang W, Liu Z, Guillen-Garcia P, Esteban CR, Reddy P, Horvath S, Li J, Geng L, Hu Q, Wang S, Belmonte JCI, Ren J, Zhang W, Qu J, Liu GH. Jing Y, et al. Among authors: geng l. Cell Stem Cell. 2023 Nov 2;30(11):1452-1471.e10. doi: 10.1016/j.stem.2023.09.007. Epub 2023 Oct 12. Cell Stem Cell. 2023. PMID: 37832549
Low-dose quercetin positively regulates mouse healthspan.
Geng L, Liu Z, Wang S, Sun S, Ma S, Liu X, Chan P, Sun L, Song M, Zhang W, Liu GH, Qu J. Geng L, et al. Protein Cell. 2019 Oct;10(10):770-775. doi: 10.1007/s13238-019-0646-8. Protein Cell. 2019. PMID: 31325157 Free PMC article. No abstract available.
Low-dose chloroquine treatment extends the lifespan of aged rats.
Li W, Zou Z, Cai Y, Yang K, Wang S, Liu Z, Geng L, Chu Q, Ji Z, Chan P, Liu GH, Song M, Qu J, Zhang W. Li W, et al. Among authors: geng l. Protein Cell. 2022 Jun;13(6):454-461. doi: 10.1007/s13238-021-00903-1. Protein Cell. 2022. PMID: 35023015 Free PMC article. No abstract available.
Cross-species metabolomic analysis identifies uridine as a potent regeneration promoting factor.
Liu Z, Li W, Geng L, Sun L, Wang Q, Yu Y, Yan P, Liang C, Ren J, Song M, Zhao Q, Lei J, Cai Y, Li J, Yan K, Wu Z, Chu Q, Li J, Wang S, Li C, Han JJ, Hernandez-Benitez R, Shyh-Chang N, Belmonte JCI, Zhang W, Qu J, Liu GH. Liu Z, et al. Among authors: geng l. Cell Discov. 2022 Feb 1;8(1):6. doi: 10.1038/s41421-021-00361-3. Cell Discov. 2022. PMID: 35102134 Free PMC article.
1,843 results