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Trabectedin Inhibits EWS-FLI1 and Evicts SWI/SNF from Chromatin in a Schedule-dependent Manner.
Harlow ML, Chasse MH, Boguslawski EA, Sorensen KM, Gedminas JM, Kitchen-Goosen SM, Rothbart SB, Taslim C, Lessnick SL, Peck AS, Madaj ZB, Bowman MJ, Grohar PJ. Harlow ML, et al. Among authors: gedminas jm. Clin Cancer Res. 2019 Jun 1;25(11):3417-3429. doi: 10.1158/1078-0432.CCR-18-3511. Epub 2019 Feb 5. Clin Cancer Res. 2019. PMID: 30723142 Free PMC article.
Targeting the DNA damage response in pediatric malignancies.
Gedminas JM, Laetsch TW. Gedminas JM, et al. Expert Rev Anticancer Ther. 2022 Oct;22(10):1099-1113. doi: 10.1080/14737140.2022.2124970. Epub 2022 Sep 23. Expert Rev Anticancer Ther. 2022. PMID: 36099180 Review.
Cell Context is the third axis of synergy for the combination of ATR inhibition and cisplatin in Ewing sarcoma.
Jess J, Sorensen KM, Boguslawski EA, Stout MC, Madaj ZB, Caiello BP, Pomaville M, Wilson ER, Kinn-Gurzo SS, Parker CC, Veluvolu SM, Brysgel TV, Kaufman R, Kitchen-Goosen SM, Gedminas JM, Grohar PJ. Jess J, et al. Among authors: gedminas jm. Clin Cancer Res. 2024 Mar 20. doi: 10.1158/1078-0432.CCR-23-3063. Online ahead of print. Clin Cancer Res. 2024. PMID: 38506712