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Inhibiting Hippo pathway kinases releases WWC1 to promote AMPAR-dependent synaptic plasticity and long-term memory in mice.
Stepan J, Heinz DE, Dethloff F, Wiechmann S, Martinelli S, Hafner K, Ebert T, Junglas E, Häusl AS, Pöhlmann ML, Jakovcevski M, Pape JC, Zannas AS, Bajaj T, Hermann A, Ma X, Pavenstädt H, Schmidt MV, Philipsen A, Turck CW, Deussing JM, Rammes G, Robinson AC, Payton A, Wehr MC, Stein V, Murgatroyd C, Kremerskothen J, Kuster B, Wotjak CT, Gassen NC. Stepan J, et al. Among authors: gassen nc. Sci Signal. 2024 Apr 30;17(834):eadj6603. doi: 10.1126/scisignal.adj6603. Epub 2024 Apr 30. Sci Signal. 2024. PMID: 38687825
SKA2 regulated hyperactive secretory autophagy drives neuroinflammation-induced neurodegeneration.
Hartmann J, Bajaj T, Otten J, Klengel C, Ebert T, Gellner AK, Junglas E, Hafner K, Anderzhanova EA, Tang F, Missig G, Rexrode L, Trussell DT, Li KX, Pöhlmann ML, Mackert S, Geiger TM, Heinz DE, Lardenoije R, Dedic N, McCullough KM, Próchnicki T, Rhomberg T, Martinelli S, Payton A, Robinson AC, Stein V, Latz E, Carlezon WA Jr, Hausch F, Schmidt MV, Murgatroyd C, Berretta S, Klengel T, Pantazopoulos H, Ressler KJ, Gassen NC. Hartmann J, et al. Among authors: gassen nc. Nat Commun. 2024 Mar 25;15(1):2635. doi: 10.1038/s41467-024-46953-x. Nat Commun. 2024. PMID: 38528004 Free PMC article.
Proteomic and transcriptomic profiling of brainstem, cerebellum and olfactory tissues in early- and late-phase COVID-19.
Radke J, Meinhardt J, Aschman T, Chua RL, Farztdinov V, Lukassen S, Ten FW, Friebel E, Ishaque N, Franz J, Huhle VH, Mothes R, Peters K, Thomas C, Schneeberger S, Schumann E, Kawelke L, Jünger J, Horst V, Streit S, von Manitius R, Körtvélyessy P, Vielhaber S, Reinhold D, Hauser AE, Osterloh A, Enghard P, Ihlow J, Elezkurtaj S, Horst D, Kurth F, Müller MA, Gassen NC, Melchert J, Jechow K, Timmermann B, Fernandez-Zapata C, Böttcher C, Stenzel W, Krüger E, Landthaler M, Wyler E, Corman V, Stadelmann C, Ralser M, Eils R, Heppner FL, Mülleder M, Conrad C, Radbruch H. Radke J, et al. Among authors: gassen nc. Nat Neurosci. 2024 Mar;27(3):409-420. doi: 10.1038/s41593-024-01573-y. Epub 2024 Feb 16. Nat Neurosci. 2024. PMID: 38366144
Single-Nucleus Transcriptome Profiling of Dorsolateral Prefrontal Cortex: Mechanistic Roles for Neuronal Gene Expression, Including the 17q21.31 Locus, in PTSD Stress Response.
Chatzinakos C, Pernia CD, Morrison FG, Iatrou A, McCullough KM, Schuler H, Snijders C, Bajaj T, DiPietro CP, Soliva Estruch M, Gassen NC, Anastasopoulos C, Bharadwaj RA, Bowlby BC, Hartmann J, Maihofer AX, Nievergelt CM, Ressler NM, Wolf EJ; Traumatic Stress Brain Research Group; PTSD BrainOmics Project of the PsychENCODE Consortium; PTSD Working Group of the Psychiatric Genomics Consortium; Carlezon WA Jr, Krystal JH, Kleinman JE, Girgenti MJ, Huber BR, Kellis M, Logue MW, Miller MW, Ressler KJ, Daskalakis NP. Chatzinakos C, et al. Among authors: gassen nc. Am J Psychiatry. 2023 Oct 1;180(10):739-754. doi: 10.1176/appi.ajp.20220478. Epub 2023 Jul 26. Am J Psychiatry. 2023. PMID: 37491937
SKA2 regulated hyperactive secretory autophagy drives neuroinflammation-induced neurodegeneration.
Hartmann J, Bajaj T, Otten J, Klengel C, Gellner AK, Junglas E, Hafner K, Anderzhanova EA, Tang F, Missig G, Rexrode L, Li K, Pöhlmann ML, Heinz DE, Lardenoije R, Dedic N, McCullough KM, Próchnicki T, Rhomberg T, Martinelli S, Payton A, Robinson AC, Stein V, Latz E, Carlezon WA, Schmidt MV, Murgatroyd C, Berretta S, Klengel T, Pantazopoulos H, Ressler KJ, Gassen NC. Hartmann J, et al. Among authors: gassen nc. bioRxiv [Preprint]. 2023 Apr 3:2023.04.03.534570. doi: 10.1101/2023.04.03.534570. bioRxiv. 2023. PMID: 37066393 Free PMC article. Updated. Preprint.
Associations of psychiatric disease and ageing with FKBP5 expression converge on superficial layer neurons of the neocortex.
Matosin N, Arloth J, Czamara D, Edmond KZ, Maitra M, Fröhlich AS, Martinelli S, Kaul D, Bartlett R, Curry AR, Gassen NC, Hafner K, Müller NS, Worf K, Rehawi G, Nagy C, Halldorsdottir T, Cruceanu C, Gagliardi M, Gerstner N, Ködel M, Murek V, Ziller MJ, Scarr E, Tao R, Jaffe AE, Arzberger T, Falkai P, Kleinmann JE, Weinberger DR, Mechawar N, Schmitt A, Dean B, Turecki G, Hyde TM, Binder EB. Matosin N, et al. Among authors: gassen nc. Acta Neuropathol. 2023 Apr;145(4):439-459. doi: 10.1007/s00401-023-02541-9. Epub 2023 Feb 2. Acta Neuropathol. 2023. PMID: 36729133 Free PMC article.
Hippo-released WWC1 facilitates AMPA receptor regulatory complexes for hippocampal learning.
Stepan J, Heinz DE, Dethloff F, Bajaj T, Zellner A, Hafner K, Wiechmann S, Mackert S, Mecdad Y, Rabenstein M, Ebert T, Martinelli S, Häusl AS, Pöhlmann ML, Hermann A, Ma X, Pavenstädt H, Schmidt MV, Philipsen A, Turck CW, Deussing JM, Kuster B, Wehr MC, Stein V, Kremerskothen J, Wotjak CT, Gassen NC. Stepan J, et al. Among authors: gassen nc. Cell Rep. 2022 Dec 6;41(10):111766. doi: 10.1016/j.celrep.2022.111766. Cell Rep. 2022. PMID: 36476872 Free article.
60 results