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De novo NAD+ synthesis enhances mitochondrial function and improves health.
Katsyuba E, Mottis A, Zietak M, De Franco F, van der Velpen V, Gariani K, Ryu D, Cialabrini L, Matilainen O, Liscio P, Giacchè N, Stokar-Regenscheit N, Legouis D, de Seigneux S, Ivanisevic J, Raffaelli N, Schoonjans K, Pellicciari R, Auwerx J. Katsyuba E, et al. Among authors: gariani k. Nature. 2018 Nov;563(7731):354-359. doi: 10.1038/s41586-018-0645-6. Epub 2018 Oct 24. Nature. 2018. PMID: 30356218 Free PMC article.
[Diabetic nephropathy: an update].
Gariani K, de Seigneux S, Pechère-Bertschi A, Philippe J, Martin PY. Gariani K, et al. Rev Med Suisse. 2012 Feb 29;8(330):473-9. Rev Med Suisse. 2012. PMID: 22452134 Review. French.
Eliciting the mitochondrial unfolded protein response by nicotinamide adenine dinucleotide repletion reverses fatty liver disease in mice.
Gariani K, Menzies KJ, Ryu D, Wegner CJ, Wang X, Ropelle ER, Moullan N, Zhang H, Perino A, Lemos V, Kim B, Park YK, Piersigilli A, Pham TX, Yang Y, Ku CS, Koo SI, Fomitchova A, Cantó C, Schoonjans K, Sauve AA, Lee JY, Auwerx J. Gariani K, et al. Hepatology. 2016 Apr;63(4):1190-204. doi: 10.1002/hep.28245. Epub 2015 Dec 16. Hepatology. 2016. PMID: 26404765 Free PMC article.
NAD+ repletion improves muscle function in muscular dystrophy and counters global PARylation.
Ryu D, Zhang H, Ropelle ER, Sorrentino V, Mázala DA, Mouchiroud L, Marshall PL, Campbell MD, Ali AS, Knowels GM, Bellemin S, Iyer SR, Wang X, Gariani K, Sauve AA, Cantó C, Conley KE, Walter L, Lovering RM, Chin ER, Jasmin BJ, Marcinek DJ, Menzies KJ, Auwerx J. Ryu D, et al. Among authors: gariani k. Sci Transl Med. 2016 Oct 19;8(361):361ra139. doi: 10.1126/scitranslmed.aaf5504. Sci Transl Med. 2016. PMID: 27798264 Free PMC article.
PARP inhibition protects against alcoholic and non-alcoholic steatohepatitis.
Mukhopadhyay P, Horváth B, Rajesh M, Varga ZV, Gariani K, Ryu D, Cao Z, Holovac E, Park O, Zhou Z, Xu MJ, Wang W, Godlewski G, Paloczi J, Nemeth BT, Persidsky Y, Liaudet L, Haskó G, Bai P, Boulares AH, Auwerx J, Gao B, Pacher P. Mukhopadhyay P, et al. Among authors: gariani k. J Hepatol. 2017 Mar;66(3):589-600. doi: 10.1016/j.jhep.2016.10.023. Epub 2016 Oct 29. J Hepatol. 2017. PMID: 27984176
An Integrated Systems Genetics and Omics Toolkit to Probe Gene Function.
Li H, Wang X, Rukina D, Huang Q, Lin T, Sorrentino V, Zhang H, Bou Sleiman M, Arends D, McDaid A, Luan P, Ziari N, Velázquez-Villegas LA, Gariani K, Kutalik Z, Schoonjans K, Radcliffe RA, Prins P, Morgenthaler S, Williams RW, Auwerx J. Li H, et al. Among authors: gariani k. Cell Syst. 2018 Jan 24;6(1):90-102.e4. doi: 10.1016/j.cels.2017.10.016. Epub 2017 Nov 30. Cell Syst. 2018. PMID: 29199021 Free article.
98 results