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CPT1A in AgRP neurons is required for sex-dependent regulation of feeding and thirst.
Zagmutt S, Mera P, González-García I, Ibeas K, Romero MDM, Obri A, Martin B, Esteve-Codina A, Soler-Vázquez MC, Bastias-Pérez M, Cañes L, Augé E, Pelegri C, Vilaplana J, Ariza X, García J, Martinez-González J, Casals N, López M, Palmiter R, Sanz E, Quintana A, Herrero L, Serra D. Zagmutt S, et al. Among authors: garcia j. Biol Sex Differ. 2023 Mar 25;14(1):14. doi: 10.1186/s13293-023-00498-8. Biol Sex Differ. 2023. PMID: 36966335 Free PMC article.
C75 is converted to C75-CoA in the hypothalamus, where it inhibits carnitine palmitoyltransferase 1 and decreases food intake and body weight.
Mera P, Bentebibel A, López-Viñas E, Cordente AG, Gurunathan C, Sebastián D, Vázquez I, Herrero L, Ariza X, Gómez-Puertas P, Asins G, Serra D, García J, Hegardt FG. Mera P, et al. Among authors: garcia j. Biochem Pharmacol. 2009 Mar 15;77(6):1084-95. doi: 10.1016/j.bcp.2008.11.020. Epub 2008 Nov 27. Biochem Pharmacol. 2009. PMID: 19094968
Nanomedicine targeting brain lipid metabolism as a feasible approach for controlling the energy balance.
Garcia-Chica J, Paraiso WKD, Zagmutt S, Fosch A, Reguera AC, Alzina S, Sánchez-García L, Fukushima S, Toh K, Casals N, Serra D, Herrero L, Garcia J, Kataoka K, Ariza X, Quader S, Rodríguez-Rodríguez R. Garcia-Chica J, et al. Among authors: garcia j. Biomater Sci. 2023 Mar 28;11(7):2336-2347. doi: 10.1039/d2bm01751b. Biomater Sci. 2023. PMID: 36804651
An overview of nanomedicines for neuron targeting.
Garcia-Chica J, D Paraiso WK, Tanabe S, Serra D, Herrero L, Casals N, Garcia J, Ariza X, Quader S, Rodriguez-Rodriguez R. Garcia-Chica J, et al. Among authors: garcia j. Nanomedicine (Lond). 2020 Jul;15(16):1617-1636. doi: 10.2217/nnm-2020-0088. Epub 2020 Jul 3. Nanomedicine (Lond). 2020. PMID: 32618490 Review.
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