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Genotoxic aldehyde stress prematurely ages hematopoietic stem cells in a p53-driven manner.
Wang M, Brandt LTL, Wang X, Russell H, Mitchell E, Kamimae-Lanning AN, Brown JM, Dingler FA, Garaycoechea JI, Isobe T, Kinston SJ, Gu M, Vassiliou GS, Wilson NK, Göttgens B, Patel KJ. Wang M, et al. Among authors: garaycoechea ji. Mol Cell. 2023 Jul 20;83(14):2417-2433.e7. doi: 10.1016/j.molcel.2023.05.035. Epub 2023 Jun 21. Mol Cell. 2023. PMID: 37348497 Free PMC article.
Aldehyde-driven transcriptional stress triggers an anorexic DNA damage response.
Mulderrig L, Garaycoechea JI, Tuong ZK, Millington CL, Dingler FA, Ferdinand JR, Gaul L, Tadross JA, Arends MJ, O'Rahilly S, Crossan GP, Clatworthy MR, Patel KJ. Mulderrig L, et al. Among authors: garaycoechea ji. Nature. 2021 Dec;600(7887):158-163. doi: 10.1038/s41586-021-04133-7. Epub 2021 Nov 24. Nature. 2021. PMID: 34819667
Endogenous Formaldehyde Is a Hematopoietic Stem Cell Genotoxin and Metabolic Carcinogen.
Pontel LB, Rosado IV, Burgos-Barragan G, Garaycoechea JI, Yu R, Arends MJ, Chandrasekaran G, Broecker V, Wei W, Liu L, Swenberg JA, Crossan GP, Patel KJ. Pontel LB, et al. Among authors: garaycoechea ji. Mol Cell. 2015 Oct 1;60(1):177-88. doi: 10.1016/j.molcel.2015.08.020. Epub 2015 Sep 24. Mol Cell. 2015. PMID: 26412304 Free PMC article.
Why does the bone marrow fail in Fanconi anemia?
Garaycoechea JI, Patel KJ. Garaycoechea JI, et al. Blood. 2014 Jan 2;123(1):26-34. doi: 10.1182/blood-2013-09-427740. Epub 2013 Nov 7. Blood. 2014. PMID: 24200684 Free article. Review.
Alcohol and endogenous aldehydes damage chromosomes and mutate stem cells.
Garaycoechea JI, Crossan GP, Langevin F, Mulderrig L, Louzada S, Yang F, Guilbaud G, Park N, Roerink S, Nik-Zainal S, Stratton MR, Patel KJ. Garaycoechea JI, et al. Nature. 2018 Jan 11;553(7687):171-177. doi: 10.1038/nature25154. Epub 2018 Jan 3. Nature. 2018. PMID: 29323295 Free PMC article.
[Aldehydes and Fanconi anaemia: the enemy within].
Langevin FP, Garaycoechea JI, Crossan GP, Patel KJ. Langevin FP, et al. Among authors: garaycoechea ji. Med Sci (Paris). 2013 Apr;29(4):361-4. doi: 10.1051/medsci/2013294009. Epub 2013 Apr 26. Med Sci (Paris). 2013. PMID: 23621931 Free article. French. No abstract available.
17 results