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Hypoxia-inducible factor 1α (HIF-1α) is a major determinant in the enhanced function of muscle-derived progenitors from MRL/MpJ mice.
Sinha KM, Tseng C, Guo P, Lu A, Pan H, Gao X, Andrews R, Eltzschig H, Huard J. Sinha KM, et al. Among authors: gao x. FASEB J. 2019 Jul;33(7):8321-8334. doi: 10.1096/fj.201801794R. Epub 2019 Apr 10. FASEB J. 2019. PMID: 30970214 Free PMC article.
Taken together, our findings suggest that HIF-1alpha is a major determinant in the increased MDSPC function of MRL/MpJ mice through enhancement of cell survival, proliferation, and myogenic differentiation.-Sinha, K. M., Tseng, C., Guo, P., Lu, A., Pan, H., Gao, X., …
Taken together, our findings suggest that HIF-1alpha is a major determinant in the increased MDSPC function of MRL/MpJ mice through enhancem …
Characterization of articular cartilage homeostasis and the mechanism of superior cartilage regeneration of MRL/MpJ mice.
Deng Z, Gao X, Sun X, Amra S, Lu A, Cui Y, Eltzschig HK, Lei G, Huard J. Deng Z, et al. Among authors: gao x. FASEB J. 2019 Aug;33(8):8809-8821. doi: 10.1096/fj.201802132RR. Epub 2019 May 1. FASEB J. 2019. PMID: 31042406
Collectively, our study revealed that down-regulation of pSMAD2/3, beta-catenin, and MMPs and up-regulation of pSMAD5 and M2a macrophage polarization contribute to the enhanced cartilage repair observed in MRL/MpJ mice.-Deng, Z., Gao, X., Sun, X., Amra, S., L …
Collectively, our study revealed that down-regulation of pSMAD2/3, beta-catenin, and MMPs and up-regulation of pSMAD5 and M2a macrophage pol …
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