Gao LA - Search Results

1

UG/Abi: a highly diverse family of prokaryotic reverse transcriptases associated with defense functions.

Mestre MR, Gao LA, Shah SA, López-Beltrán A, González-Delgado A, Martínez-Abarca F, Iranzo J, Redrejo-Rodríguez M, Zhang F, Toro N. Mestre MR, et al. Among authors: gao la. Nucleic Acids Res. 2022 Jun 24;50(11):6084-6101. doi: 10.1093/nar/gkac467. Nucleic Acids Res. 2022. PMID: 35648479 Free PMC article.

2

Rationally engineered Cas9 nucleases with improved specificity.

Slaymaker IM, Gao L, Zetsche B, Scott DA, Yan WX, Zhang F. Slaymaker IM, et al. Science. 2016 Jan 1;351(6268):84-8. doi: 10.1126/science.aad5227. Epub 2015 Dec 1. Science. 2016. PMID: 26628643 Free PMC article.

3

Engineered Cpf1 variants with altered PAM specificities.

Gao L, Cox DBT, Yan WX, Manteiga JC, Schneider MW, Yamano T, Nishimasu H, Nureki O, Crosetto N, Zhang F. Gao L, et al. Nat Biotechnol. 2017 Aug;35(8):789-792. doi: 10.1038/nbt.3900. Epub 2017 Jun 5. Nat Biotechnol. 2017. PMID: 28581492 Free PMC article.

4

Structural Basis for the Altered PAM Recognition by Engineered CRISPR-Cpf1.

Nishimasu H, Yamano T, Gao L, Zhang F, Ishitani R, Nureki O. Nishimasu H, et al. Mol Cell. 2017 Jul 6;67(1):139-147.e2. doi: 10.1016/j.molcel.2017.04.019. Epub 2017 Jun 6. Mol Cell. 2017. PMID: 28595896 Free PMC article.

5

Engineering of CRISPR-Cas12b for human genome editing.

Strecker J, Jones S, Koopal B, Schmid-Burgk J, Zetsche B, Gao L, Makarova KS, Koonin EV, Zhang F. Strecker J, et al. Nat Commun. 2019 Jan 22;10(1):212. doi: 10.1038/s41467-018-08224-4. Nat Commun. 2019. PMID: 30670702 Free PMC article.

6

Unexpected connections between type VI-B CRISPR-Cas systems, bacterial natural competence, ubiquitin signaling network and DNA modification through a distinct family of membrane proteins.

Makarova KS, Gao L, Zhang F, Koonin EV. Makarova KS, et al. FEMS Microbiol Lett. 2019 Apr 1;366(8):fnz088. doi: 10.1093/femsle/fnz088. FEMS Microbiol Lett. 2019. PMID: 31089700 Free PMC article.

7

Highly Parallel Profiling of Cas9 Variant Specificity.

Schmid-Burgk JL, Gao L, Li D, Gardner Z, Strecker J, Lash B, Zhang F. Schmid-Burgk JL, et al. Mol Cell. 2020 May 21;78(4):794-800.e8. doi: 10.1016/j.molcel.2020.02.023. Epub 2020 Mar 17. Mol Cell. 2020. PMID: 32187529 Free PMC article.

8

Diverse enzymatic activities mediate antiviral immunity in prokaryotes.

Gao L, Altae-Tran H, Böhning F, Makarova KS, Segel M, Schmid-Burgk JL, Koob J, Wolf YI, Koonin EV, Zhang F. Gao L, et al. Science. 2020 Aug 28;369(6507):1077-1084. doi: 10.1126/science.aba0372. Science. 2020. PMID: 32855333 Free PMC article.

9

Prokaryotic innate immunity through pattern recognition of conserved viral proteins.

Gao LA, Wilkinson ME, Strecker J, Makarova KS, Macrae RK, Koonin EV, Zhang F. Gao LA, et al. Science. 2022 Aug 12;377(6607):eabm4096. doi: 10.1126/science.abm4096. Epub 2022 Aug 12. Science. 2022. PMID: 35951700 Free PMC article.

10

Computational Identification of Repeat-Containing Proteins and Systems.

Altae-Tran H, Gao L, Strecker J, Macrae RK, Zhang F. Altae-Tran H, et al. QRB Discov. 2020 Oct 20;1:e10. doi: 10.1017/qrd.2020.14. eCollection 2020. QRB Discov. 2020. PMID: 37528961 Free PMC article.

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