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Mitochondrial DNA mutations drive aerobic glycolysis to enhance checkpoint blockade response in melanoma.
Mahmood M, Liu EM, Shergold AL, Tolla E, Tait-Mulder J, Huerta-Uribe A, Shokry E, Young AL, Lilla S, Kim M, Park T, Boscenco S, Manchon JL, Rodríguez-Antona C, Walters RC, Springett RJ, Blaza JN, Mitchell L, Blyth K, Zanivan S, Sumpton D, Roberts EW, Reznik E, Gammage PA. Mahmood M, et al. Among authors: gammage pa. Nat Cancer. 2024 Apr;5(4):659-672. doi: 10.1038/s43018-023-00721-w. Epub 2024 Jan 29. Nat Cancer. 2024. PMID: 38286828 Free PMC article.
Mitonuclear genotype remodels the metabolic and microenvironmental landscape of Hürthle cell carcinoma.
Ganly I, Liu EM, Kuo F, Makarov V, Dong Y, Park J, Gong Y, Gorelick AN, Knauf JA, Benedetti E, Tait-Mulder J, Morris LGT, Fagin JA, Intlekofer AM, Krumsiek J, Gammage PA, Ghossein R, Xu B, Chan TA, Reznik E. Ganly I, et al. Among authors: gammage pa. Sci Adv. 2022 Jun 24;8(25):eabn9699. doi: 10.1126/sciadv.abn9699. Epub 2022 Jun 22. Sci Adv. 2022. PMID: 35731870 Free PMC article.
Mitochondrial DNA is a major source of driver mutations in cancer.
Kim M, Mahmood M, Reznik E, Gammage PA. Kim M, et al. Among authors: gammage pa. Trends Cancer. 2022 Dec;8(12):1046-1059. doi: 10.1016/j.trecan.2022.08.001. Epub 2022 Aug 27. Trends Cancer. 2022. PMID: 36041967 Free PMC article. Review.
Tumour mitochondrial DNA mutations drive aerobic glycolysis to enhance checkpoint blockade.
Mahmood M, Liu EM, Shergold AL, Tolla E, Tait-Mulder J, Huerta Uribe A, Shokry E, Young AL, Lilla S, Kim M, Park T, Manchon JL, Rodríguez-Antona C, Walters RC, Springett RJ, Blaza JN, Zanivan S, Sumpton D, Roberts EW, Reznik E, Gammage PA. Mahmood M, et al. Among authors: gammage pa. bioRxiv [Preprint]. 2023 Mar 23:2023.03.21.533091. doi: 10.1101/2023.03.21.533091. bioRxiv. 2023. PMID: 36993533 Free PMC article. Updated. Preprint.
Single-cell mtDNA dynamics in tumors is driven by coregulation of nuclear and mitochondrial genomes.
Kim M, Gorelick AN, Vàzquez-García I, Williams MJ, Salehi S, Shi H, Weiner AC, Ceglia N, Funnell T, Park T, Boscenco S, O'Flanagan CH, Jiang H, Grewal D, Tang C, Rusk N, Gammage PA, McPherson A, Aparicio S, Shah SP, Reznik E. Kim M, et al. Among authors: gammage pa. Nat Genet. 2024 May;56(5):889-899. doi: 10.1038/s41588-024-01724-8. Epub 2024 May 13. Nat Genet. 2024. PMID: 38741018 Free PMC article.
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