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GSK2256294 Decreases sEH (Soluble Epoxide Hydrolase) Activity in Plasma, Muscle, and Adipose and Reduces F2-Isoprostanes but Does Not Alter Insulin Sensitivity in Humans.
Luther JM, Ray J, Wei D, Koethe JR, Hannah L, DeMatteo A, Manning R, Terker AS, Peng D, Nian H, Yu C, Mashayekhi M, Gamboa J, Brown NJ. Luther JM, et al. Hypertension. 2021 Sep;78(4):1092-1102. doi: 10.1161/HYPERTENSIONAHA.121.17659. Epub 2021 Aug 30. Hypertension. 2021. PMID: 34455816 Free PMC article. Clinical Trial.
Insulin resistance is a significant determinant of sarcopenia in advanced kidney disease.
Deger SM, Hewlett JR, Gamboa J, Ellis CD, Hung AM, Siew ED, Mamnungu C, Sha F, Bian A, Stewart TG, Abumrad NN, Ikizler TA. Deger SM, et al. Am J Physiol Endocrinol Metab. 2018 Dec 1;315(6):E1108-E1120. doi: 10.1152/ajpendo.00070.2018. Epub 2018 Jun 12. Am J Physiol Endocrinol Metab. 2018. PMID: 29894202 Free PMC article. Clinical Trial.
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