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The Tankyrase Inhibitor OM-153 Demonstrates Antitumor Efficacy and a Therapeutic Window in Mouse Models.
Brinch SA, Amundsen-Isaksen E, Espada S, Hammarström C, Aizenshtadt A, Olsen PA, Holmen L, Høyem M, Scholz H, Grødeland G, Sowa ST, Galera-Prat A, Lehtiö L, Meerts IATM, Leenders RGG, Wegert A, Krauss S, Waaler J. Brinch SA, et al. Among authors: galera prat a. Cancer Res Commun. 2022 Apr 20;2(4):233-245. doi: 10.1158/2767-9764.CRC-22-0027. eCollection 2022 Apr. Cancer Res Commun. 2022. PMID: 36873622 Free PMC article.
Preclinical Lead Optimization of a 1,2,4-Triazole Based Tankyrase Inhibitor.
Waaler J, Leenders RGG, Sowa ST, Alam Brinch S, Lycke M, Nieczypor P, Aertssen S, Murthy S, Galera-Prat A, Damen E, Wegert A, Nazaré M, Lehtiö L, Krauss S. Waaler J, et al. J Med Chem. 2020 Jul 9;63(13):6834-6846. doi: 10.1021/acs.jmedchem.0c00208. Epub 2020 Jun 23. J Med Chem. 2020. PMID: 32511917 Free PMC article.
A molecular toolbox for ADP-ribosyl binding proteins.
Sowa ST, Galera-Prat A, Wazir S, Alanen HI, Maksimainen MM, Lehtiö L. Sowa ST, et al. Cell Rep Methods. 2021 Dec 20;1(8):100121. doi: 10.1016/j.crmeth.2021.100121. Epub 2021 Nov 11. Cell Rep Methods. 2021. PMID: 34786571 Free PMC article.
Analogs of TIQ-A as inhibitors of human mono-ADP-ribosylating PARPs.
Maksimainen MM, Murthy S, Sowa ST, Galera-Prat A, Rolina E, Heiskanen JP, Lehtiö L. Maksimainen MM, et al. Bioorg Med Chem. 2021 Dec 15;52:116511. doi: 10.1016/j.bmc.2021.116511. Epub 2021 Nov 10. Bioorg Med Chem. 2021. PMID: 34801828 Free article.
Development of a 1,2,4-Triazole-Based Lead Tankyrase Inhibitor: Part II.
Leenders RGG, Brinch SA, Sowa ST, Amundsen-Isaksen E, Galera-Prat A, Murthy S, Aertssen S, Smits JN, Nieczypor P, Damen E, Wegert A, Nazaré M, Lehtiö L, Waaler J, Krauss S. Leenders RGG, et al. J Med Chem. 2021 Dec 23;64(24):17936-17949. doi: 10.1021/acs.jmedchem.1c01264. Epub 2021 Dec 8. J Med Chem. 2021. PMID: 34878777 Free PMC article.
33 results