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Pilot Study to Quantify Palladium Impurities in Lead-like Compounds Following Commonly Used Purification Techniques.
Chatzopoulou M, Madden KS, Bromhead LJ, Greaves C, Cogswell TJ, Da Silva Pinto S, Galan SRG, Georgiou I, Kennedy MS, Kennett A, Apps G, Russell AJ, Wynne GM. Chatzopoulou M, et al. Among authors: galan srg. ACS Med Chem Lett. 2022 Jan 20;13(2):262-270. doi: 10.1021/acsmedchemlett.1c00638. eCollection 2022 Feb 10. ACS Med Chem Lett. 2022. PMID: 35173892 Free PMC article.
Phenotypic screening identifies a trisubstituted imidazo[1,2-a]pyridine series that induces differentiation in multiple AML cell lines.
Josa-Culleré L, Galan SRG, Cogswell TJ, Jackson TR, Jay-Smith M, Mola L, Greaves CR, Carter TS, Madden KS, Trott S, Zhang D, Bataille CJR, Davies SG, Vyas P, Milne TA, Naylor A, Wynne GM, Russell AJ. Josa-Culleré L, et al. Among authors: galan srg. Eur J Med Chem. 2023 Oct 5;258:115509. doi: 10.1016/j.ejmech.2023.115509. Epub 2023 May 26. Eur J Med Chem. 2023. PMID: 37343464
Post-translational site-selective protein backbone α-deuteration.
Galan SRG, Wickens JR, Dadova J, Ng WL, Zhang X, Simion RA, Quinlan R, Pires E, Paton RS, Caddick S, Chudasama V, Davis BG. Galan SRG, et al. Nat Chem Biol. 2018 Oct;14(10):955-963. doi: 10.1038/s41589-018-0128-y. Epub 2018 Sep 17. Nat Chem Biol. 2018. PMID: 30224694
Non-benzimidazole containing inhibitors of respiratory syncytial virus.
Pryde DC, Tran TD, Gardner I, Bright H, Stupple P, Galan S, Alsop L, Watson L, Middleton DS, Dayal S, Platts M, Murray EJ, Parkinson T, Webster R. Pryde DC, et al. Bioorg Med Chem Lett. 2013 Feb 1;23(3):827-33. doi: 10.1016/j.bmcl.2012.11.062. Epub 2012 Nov 29. Bioorg Med Chem Lett. 2013. PMID: 23265891
Posttranslational mutagenesis: A chemical strategy for exploring protein side-chain diversity.
Wright TH, Bower BJ, Chalker JM, Bernardes GJ, Wiewiora R, Ng WL, Raj R, Faulkner S, Vallée MR, Phanumartwiwath A, Coleman OD, Thézénas ML, Khan M, Galan SR, Lercher L, Schombs MW, Gerstberger S, Palm-Espling ME, Baldwin AJ, Kessler BM, Claridge TD, Mohammed S, Davis BG. Wright TH, et al. Science. 2016 Nov 4;354(6312):aag1465. doi: 10.1126/science.aag1465. Epub 2016 Sep 22. Science. 2016. PMID: 27708059
LanCLs add glutathione to dehydroamino acids generated at phosphorylated sites in the proteome.
Lai KY, Galan SRG, Zeng Y, Zhou TH, He C, Raj R, Riedl J, Liu S, Chooi KP, Garg N, Zeng M, Jones LH, Hutchings GJ, Mohammed S, Nair SK, Chen J, Davis BG, van der Donk WA. Lai KY, et al. Among authors: galan srg. Cell. 2021 May 13;184(10):2680-2695.e26. doi: 10.1016/j.cell.2021.04.001. Epub 2021 Apr 30. Cell. 2021. PMID: 33932340 Free PMC article.
15 results