Gajewiak J - Search Results

1

A structurally minimized yet fully active insulin based on cone-snail venom insulin principles.

Xiong X, Menting JG, Disotuar MM, Smith NA, Delaine CA, Ghabash G, Agrawal R, Wang X, He X, Fisher SJ, MacRaild CA, Norton RS, Gajewiak J, Forbes BE, Smith BJ, Safavi-Hemami H, Olivera B, Lawrence MC, Chou DH. Xiong X, et al. Among authors: gajewiak j. Nat Struct Mol Biol. 2020 Jul;27(7):615-624. doi: 10.1038/s41594-020-0430-8. Epub 2020 Jun 1. Nat Struct Mol Biol. 2020. PMID: 32483339 Free PMC article.

2

μ-Conotoxins that differentially block sodium channels NaV1.1 through 1.8 identify those responsible for action potentials in sciatic nerve.

Wilson MJ, Yoshikami D, Azam L, Gajewiak J, Olivera BM, Bulaj G, Zhang MM. Wilson MJ, et al. Among authors: gajewiak j. Proc Natl Acad Sci U S A. 2011 Jun 21;108(25):10302-7. doi: 10.1073/pnas.1107027108. Epub 2011 Jun 7. Proc Natl Acad Sci U S A. 2011. PMID: 21652775 Free PMC article.

3

Characterization of a venom peptide from a crassispirid gastropod.

Cabang AB, Imperial JS, Gajewiak J, Watkins M, Corneli PS, Olivera BM, Concepcion GP. Cabang AB, et al. Among authors: gajewiak j. Toxicon. 2011 Dec 1;58(8):672-80. doi: 10.1016/j.toxicon.2011.09.001. Epub 2011 Sep 12. Toxicon. 2011. PMID: 21939682 Free PMC article.

4

Stapling mimics noncovalent interactions of γ-carboxyglutamates in conantokins, peptidic antagonists of N-methyl-D-aspartic acid receptors.

Platt RJ, Han TS, Green BR, Smith MD, Skalicky J, Gruszczynski P, White HS, Olivera B, Bulaj G, Gajewiak J. Platt RJ, et al. Among authors: gajewiak j. J Biol Chem. 2012 Jun 8;287(24):20727-36. doi: 10.1074/jbc.M112.350462. Epub 2012 Apr 19. J Biol Chem. 2012. PMID: 22518838 Free PMC article.

5

Conantokins derived from the Asprella clade impart conRl-B, an N-methyl d-aspartate receptor antagonist with a unique selectivity profile for NR2B subunits.

Gowd KH, Han TS, Twede V, Gajewiak J, Smith MD, Watkins M, Platt RJ, Toledo G, White HS, Olivera BM, Bulaj G. Gowd KH, et al. Among authors: gajewiak j. Biochemistry. 2012 Jun 12;51(23):4685-92. doi: 10.1021/bi300055n. Epub 2012 May 30. Biochemistry. 2012. PMID: 22594498 Free PMC article.

6

Modulation of conotoxin structure and function is achieved through a multienzyme complex in the venom glands of cone snails.

Safavi-Hemami H, Gorasia DG, Steiner AM, Williamson NA, Karas JA, Gajewiak J, Olivera BM, Bulaj G, Purcell AW. Safavi-Hemami H, et al. Among authors: gajewiak j. J Biol Chem. 2012 Oct 5;287(41):34288-303. doi: 10.1074/jbc.M112.366781. Epub 2012 Aug 13. J Biol Chem. 2012. PMID: 22891240 Free PMC article.

7

Co-expression of Na(V)β subunits alters the kinetics of inhibition of voltage-gated sodium channels by pore-blocking μ-conotoxins.

Zhang MM, Wilson MJ, Azam L, Gajewiak J, Rivier JE, Bulaj G, Olivera BM, Yoshikami D. Zhang MM, et al. Among authors: gajewiak j. Br J Pharmacol. 2013 Apr;168(7):1597-610. doi: 10.1111/bph.12051. Br J Pharmacol. 2013. PMID: 23146020 Free PMC article.

8

Pharmacological fractionation of tetrodotoxin-sensitive sodium currents in rat dorsal root ganglion neurons by μ-conotoxins.

Zhang MM, Wilson MJ, Gajewiak J, Rivier JE, Bulaj G, Olivera BM, Yoshikami D. Zhang MM, et al. Among authors: gajewiak j. Br J Pharmacol. 2013 May;169(1):102-14. doi: 10.1111/bph.12119. Br J Pharmacol. 2013. PMID: 23351163 Free PMC article.

9

Mammalian neuronal sodium channel blocker μ-conotoxin BuIIIB has a structured N-terminus that influences potency.

Kuang Z, Zhang MM, Gupta K, Gajewiak J, Gulyas J, Balaram P, Rivier JE, Olivera BM, Yoshikami D, Bulaj G, Norton RS. Kuang Z, et al. Among authors: gajewiak j. ACS Chem Biol. 2013;8(6):1344-51. doi: 10.1021/cb300674x. Epub 2013 Apr 16. ACS Chem Biol. 2013. PMID: 23557677 Free PMC article.

10

Characterization of the peptidylglycine α-amidating monooxygenase (PAM) from the venom ducts of neogastropods, Conus bullatus and Conus geographus.

Ul-Hasan S, Burgess DM, Gajewiak J, Li Q, Hu H, Yandell M, Olivera BM, Bandyopadhyay PK. Ul-Hasan S, et al. Among authors: gajewiak j. Toxicon. 2013 Nov;74:215-24. doi: 10.1016/j.toxicon.2013.08.054. Epub 2013 Aug 29. Toxicon. 2013. PMID: 23994590 Free PMC article.

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