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Ultrasound and Transcriptomics Identify a Differential Impact of Cisplatin and Histone Deacetylation on Tumor Structure and Microenvironment in a Patient-Derived In Vivo Model of Gastric Cancer.
Venkatasamy A, Guerin E, Blanchet A, Orvain C, Devignot V, Jung M, Jung AC, Chenard MP, Romain B, Gaiddon C, Mellitzer G. Venkatasamy A, et al. Among authors: gaiddon c. Pharmaceutics. 2021 Sep 16;13(9):1485. doi: 10.3390/pharmaceutics13091485. Pharmaceutics. 2021. PMID: 34575561 Free PMC article.
A redox ruthenium compound directly targets PHD2 and inhibits the HIF1 pathway to reduce tumor angiogenesis independently of p53.
Vidimar V, Licona C, Cerón-Camacho R, Guerin E, Coliat P, Venkatasamy A, Ali M, Guenot D, Le Lagadec R, Jung AC, Freund JN, Pfeffer M, Mellitzer G, Sava G, Gaiddon C. Vidimar V, et al. Among authors: gaiddon c. Cancer Lett. 2019 Jan;440-441:145-155. doi: 10.1016/j.canlet.2018.09.029. Epub 2018 Oct 17. Cancer Lett. 2019. PMID: 30339780
Bypassing the Resistance Mechanisms of the Tumor Ecosystem by Targeting the Endoplasmic Reticulum Stress Pathway Using Ruthenium- and Osmium-Based Organometallic Compounds: An Exciting Long-Term Collaboration with Dr. Michel Pfeffer.
Gaiddon C, Gross I, Meng X, Sidhoum M, Mellitzer G, Romain B, Delhorme JB, Venkatasamy A, Jung AC, Pfeffer M. Gaiddon C, et al. Molecules. 2021 Sep 4;26(17):5386. doi: 10.3390/molecules26175386. Molecules. 2021. PMID: 34500819 Free PMC article. Review.
Induction of caspase 8 and reactive oxygen species by ruthenium-derived anticancer compounds with improved water solubility and cytotoxicity.
Vidimar V, Meng X, Klajner M, Licona C, Fetzer L, Harlepp S, Hébraud P, Sidhoum M, Sirlin C, Loeffler JP, Mellitzer G, Sava G, Pfeffer M, Gaiddon C. Vidimar V, et al. Among authors: gaiddon c. Biochem Pharmacol. 2012 Dec 1;84(11):1428-36. doi: 10.1016/j.bcp.2012.08.022. Epub 2012 Sep 1. Biochem Pharmacol. 2012. PMID: 22964219
85 results