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A redox ruthenium compound directly targets PHD2 and inhibits the HIF1 pathway to reduce tumor angiogenesis independently of p53.
Vidimar V, Licona C, Cerón-Camacho R, Guerin E, Coliat P, Venkatasamy A, Ali M, Guenot D, Le Lagadec R, Jung AC, Freund JN, Pfeffer M, Mellitzer G, Sava G, Gaiddon C. Vidimar V, et al. Among authors: gaiddon c. Cancer Lett. 2019 Jan;440-441:145-155. doi: 10.1016/j.canlet.2018.09.029. Epub 2018 Oct 17. Cancer Lett. 2019. PMID: 30339780
DNA binding to an anticancer organo-ruthenium complex.
Klajner M, Hebraud P, Sirlin C, Gaiddon C, Harlepp S. Klajner M, et al. Among authors: gaiddon c. J Phys Chem B. 2010 Nov 11;114(44):14041-7. doi: 10.1021/jp1044783. J Phys Chem B. 2010. PMID: 20961087
Rollover Cyclometalated Bipyridine Platinum Complexes as Potent Anticancer Agents: Impact of the Ancillary Ligands on the Mode of Action.
Babak MV, Pfaffeneder-Kmen M, Meier-Menches SM, Legina MS, Theiner S, Licona C, Orvain C, Hejl M, Hanif M, Jakupec MA, Keppler BK, Gaiddon C, Hartinger CG. Babak MV, et al. Among authors: gaiddon c. Inorg Chem. 2018 Mar 5;57(5):2851-2864. doi: 10.1021/acs.inorgchem.7b03210. Epub 2018 Feb 14. Inorg Chem. 2018. PMID: 29442506
From Catalysis to Cancer: Toward Structure-Activity Relationships for Benzimidazol-2-ylidene-Derived N-Heterocyclic-Carbene Complexes as Anticancer Agents.
Lam NYS, Truong D, Burmeister H, Babak MV, Holtkamp HU, Movassaghi S, Ayine-Tora DM, Zafar A, Kubanik M, Oehninger L, Söhnel T, Reynisson J, Jamieson SMF, Gaiddon C, Ott I, Hartinger CG. Lam NYS, et al. Among authors: gaiddon c. Inorg Chem. 2018 Nov 19;57(22):14427-14434. doi: 10.1021/acs.inorgchem.8b02634. Epub 2018 Nov 8. Inorg Chem. 2018. PMID: 30406647
Flavaglines as potent anticancer and cytoprotective agents.
Ribeiro N, Thuaud F, Bernard Y, Gaiddon C, Cresteil T, Hild A, Hirsch EC, Michel PP, Nebigil CG, Désaubry L. Ribeiro N, et al. Among authors: gaiddon c. J Med Chem. 2012 Nov 26;55(22):10064-73. doi: 10.1021/jm301201z. Epub 2012 Oct 23. J Med Chem. 2012. PMID: 23072299
85 results