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Bifunctional ligand design for modulating mutant p53 aggregation in cancer.
Miller JJ, Blanchet A, Orvain C, Nouchikian L, Reviriot Y, Clarke RM, Martelino D, Wilson D, Gaiddon C, Storr T. Miller JJ, et al. Among authors: gaiddon c. Chem Sci. 2019 Oct 7;10(46):10802-10814. doi: 10.1039/c9sc04151f. eCollection 2019 Dec 14. Chem Sci. 2019. PMID: 32055386 Free PMC article.
A redox ruthenium compound directly targets PHD2 and inhibits the HIF1 pathway to reduce tumor angiogenesis independently of p53.
Vidimar V, Licona C, Cerón-Camacho R, Guerin E, Coliat P, Venkatasamy A, Ali M, Guenot D, Le Lagadec R, Jung AC, Freund JN, Pfeffer M, Mellitzer G, Sava G, Gaiddon C. Vidimar V, et al. Among authors: gaiddon c. Cancer Lett. 2019 Jan;440-441:145-155. doi: 10.1016/j.canlet.2018.09.029. Epub 2018 Oct 17. Cancer Lett. 2019. PMID: 30339780
Dichloroacetate restores colorectal cancer chemosensitivity through the p53/miR-149-3p/PDK2-mediated glucose metabolic pathway.
Liang Y, Hou L, Li L, Li L, Zhu L, Wang Y, Huang X, Hou Y, Zhu D, Zou H, Gu Y, Weng X, Wang Y, Li Y, Wu T, Yao M, Gross I, Gaiddon C, Luo M, Wang J, Meng X. Liang Y, et al. Among authors: gaiddon c. Oncogene. 2020 Jan;39(2):469-485. doi: 10.1038/s41388-019-1035-8. Epub 2019 Oct 9. Oncogene. 2020. PMID: 31597953 Free PMC article.
85 results