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A redox ruthenium compound directly targets PHD2 and inhibits the HIF1 pathway to reduce tumor angiogenesis independently of p53.
Vidimar V, Licona C, Cerón-Camacho R, Guerin E, Coliat P, Venkatasamy A, Ali M, Guenot D, Le Lagadec R, Jung AC, Freund JN, Pfeffer M, Mellitzer G, Sava G, Gaiddon C. Vidimar V, et al. Among authors: gaiddon c. Cancer Lett. 2019 Jan;440-441:145-155. doi: 10.1016/j.canlet.2018.09.029. Epub 2018 Oct 17. Cancer Lett. 2019. PMID: 30339780
Preferential Response of Basal-Like Head and Neck Squamous Cell Carcinoma Cell Lines to EGFR-Targeted Therapy Depending on EREG-Driven Oncogenic Addiction.
Job S, Reyniès A, Heller B, Weiss A, Guérin E, Macabre C, Ledrappier S, Bour C, Wasylyk C, Etienne-Selloum N, Brino L, Gaiddon C, Wasylyk B, Jung AC. Job S, et al. Among authors: gaiddon c. Cancers (Basel). 2019 Jun 8;11(6):795. doi: 10.3390/cancers11060795. Cancers (Basel). 2019. PMID: 31181806 Free PMC article.
Bypassing the Resistance Mechanisms of the Tumor Ecosystem by Targeting the Endoplasmic Reticulum Stress Pathway Using Ruthenium- and Osmium-Based Organometallic Compounds: An Exciting Long-Term Collaboration with Dr. Michel Pfeffer.
Gaiddon C, Gross I, Meng X, Sidhoum M, Mellitzer G, Romain B, Delhorme JB, Venkatasamy A, Jung AC, Pfeffer M. Gaiddon C, et al. Molecules. 2021 Sep 4;26(17):5386. doi: 10.3390/molecules26175386. Molecules. 2021. PMID: 34500819 Free PMC article. Review.
Ultrasound and Transcriptomics Identify a Differential Impact of Cisplatin and Histone Deacetylation on Tumor Structure and Microenvironment in a Patient-Derived In Vivo Model of Gastric Cancer.
Venkatasamy A, Guerin E, Blanchet A, Orvain C, Devignot V, Jung M, Jung AC, Chenard MP, Romain B, Gaiddon C, Mellitzer G. Venkatasamy A, et al. Among authors: gaiddon c. Pharmaceutics. 2021 Sep 16;13(9):1485. doi: 10.3390/pharmaceutics13091485. Pharmaceutics. 2021. PMID: 34575561 Free PMC article.
85 results