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3-hydroxy-L-kynurenamine is an immunomodulatory biogenic amine.
Clement CC, D'Alessandro A, Thangaswamy S, Chalmers S, Furtado R, Spada S, Mondanelli G, Ianni F, Gehrke S, Gargaro M, Manni G, Cara LCL, Runge P, Tsai WL, Karaman S, Arasa J, Fernandez-Rodriguez R, Beck A, Macchiarulo A, Gadina M, Halin C, Fallarino F, Skobe M, Veldhoen M, Moretti S, Formenti S, Demaria S, Soni RK, Galarini R, Sardella R, Lauvau G, Putterman C, Alitalo K, Grohmann U, Santambrogio L. Clement CC, et al. Among authors: gadina m. Nat Commun. 2021 Jul 21;12(1):4447. doi: 10.1038/s41467-021-24785-3. Nat Commun. 2021. PMID: 34290243 Free PMC article.
Editorial: JAK inhibition in autoimmune and inflammatory diseases.
Telliez JB, Gadina M, Ghoreschi K, Silvennoinen O, Spinelli FR. Telliez JB, et al. Among authors: gadina m. Front Immunol. 2022 Dec 28;13:1120281. doi: 10.3389/fimmu.2022.1120281. eCollection 2022. Front Immunol. 2022. PMID: 36643918 Free PMC article. No abstract available.
Whole Chromosome Instability induces senescence and promotes SASP.
Andriani GA, Almeida VP, Faggioli F, Mauro M, Tsai WL, Santambrogio L, Maslov A, Gadina M, Campisi J, Vijg J, Montagna C. Andriani GA, et al. Among authors: gadina m. Sci Rep. 2016 Oct 12;6:35218. doi: 10.1038/srep35218. Sci Rep. 2016. PMID: 27731420 Free PMC article.
Second Case of HOIP Deficiency Expands Clinical Features and Defines Inflammatory Transcriptome Regulated by LUBAC.
Oda H, Beck DB, Kuehn HS, Sampaio Moura N, Hoffmann P, Ibarra M, Stoddard J, Tsai WL, Gutierrez-Cruz G, Gadina M, Rosenzweig SD, Kastner DL, Notarangelo LD, Aksentijevich I. Oda H, et al. Among authors: gadina m. Front Immunol. 2019 Mar 18;10:479. doi: 10.3389/fimmu.2019.00479. eCollection 2019. Front Immunol. 2019. PMID: 30936877 Free PMC article.
Pleiotropic consequences of metabolic stress for the major histocompatibility complex class II molecule antigen processing and presentation machinery.
Clement CC, Nanaware PP, Yamazaki T, Negroni MP, Ramesh K, Morozova K, Thangaswamy S, Graves A, Kim HJ, Li TW, Vigano' M, Soni RK, Gadina M, Tse HY, Galluzzi L, Roche PA, Denzin LK, Stern LJ, Santambrogio L. Clement CC, et al. Among authors: gadina m. Immunity. 2021 Apr 13;54(4):721-736.e10. doi: 10.1016/j.immuni.2021.02.019. Epub 2021 Mar 15. Immunity. 2021. PMID: 33725478 Free PMC article.
Phase 1 double-blind randomized safety trial of the Janus kinase inhibitor tofacitinib in systemic lupus erythematosus.
Hasni SA, Gupta S, Davis M, Poncio E, Temesgen-Oyelakin Y, Carlucci PM, Wang X, Naqi M, Playford MP, Goel RR, Li X, Biehl AJ, Ochoa-Navas I, Manna Z, Shi Y, Thomas D, Chen J, Biancotto A, Apps R, Cheung F, Kotliarov Y, Babyak AL, Zhou H, Shi R, Stagliano K, Tsai WL, Vian L, Gazaniga N, Giudice V, Lu S, Brooks SR, MacKay M, Gregersen P, Mehta NN, Remaley AT, Diamond B, O'Shea JJ, Gadina M, Kaplan MJ. Hasni SA, et al. Among authors: gadina m. Nat Commun. 2021 Jun 7;12(1):3391. doi: 10.1038/s41467-021-23361-z. Nat Commun. 2021. PMID: 34099646 Free PMC article. Clinical Trial.
PDIA3 epitope-driven immune autoreactivity contributes to hepatic damage in type 2 diabetes.
Clement CC, Osan J, Buque A, Nanaware PP, Chang YC, Perino G, Shetty M, Yamazaki T, Tsai WL, Urbanska AM, Calvo-Calle JM, Ramsamooj S, Ramsamooj S, Vergani D, Mieli-Vergani G, Terziroli Beretta-Piccoli B, Gadina M, Montagna C, Goncalves MD, Sallusto F, Galluzzi L, Soni RK, Stern LJ, Santambrogio L. Clement CC, et al. Among authors: gadina m. Sci Immunol. 2022 Aug 12;7(74):eabl3795. doi: 10.1126/sciimmunol.abl3795. Epub 2022 Aug 19. Sci Immunol. 2022. PMID: 35984892 Free PMC article.
Immune modulation: Turncoat regulatory T cells.
Gadina M, O'Shea JJ. Gadina M, et al. Nat Med. 2009 Dec;15(12):1365. doi: 10.1038/nm1209-1365. Nat Med. 2009. PMID: 19966774 Free PMC article. No abstract available.
149 results