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Page 1
Pharmacokinetics of Intranasal versus Subcutaneous Insulin in the Mouse.
Nedelcovych MT, Gadiano AJ, Wu Y, Manning AA, Thomas AG, Khuder SS, Yoo SW, Xu J, McArthur JC, Haughey NJ, Volsky DJ, Rais R, Slusher BS. Nedelcovych MT, et al. Among authors: gadiano aj. ACS Chem Neurosci. 2018 Apr 18;9(4):809-816. doi: 10.1021/acschemneuro.7b00434. Epub 2018 Jan 4. ACS Chem Neurosci. 2018. PMID: 29257872 Free PMC article.
N-(Pivaloyloxy)alkoxy-carbonyl Prodrugs of the Glutamine Antagonist 6-Diazo-5-oxo-l-norleucine (DON) as a Potential Treatment for HIV Associated Neurocognitive Disorders.
Nedelcovych MT, Tenora L, Kim BH, Kelschenbach J, Chao W, Hadas E, Jančařík A, Prchalová E, Zimmermann SC, Dash RP, Gadiano AJ, Garrett C, Furtmüller G, Oh B, Brandacher G, Alt J, Majer P, Volsky DJ, Rais R, Slusher BS. Nedelcovych MT, et al. Among authors: gadiano aj. J Med Chem. 2017 Aug 24;60(16):7186-7198. doi: 10.1021/acs.jmedchem.7b00966. Epub 2017 Aug 14. J Med Chem. 2017. PMID: 28759224 Free PMC article.
Enhanced Brain Delivery of 2-(Phosphonomethyl)pentanedioic Acid Following Intranasal Administration of Its γ-Substituted Ester Prodrugs.
Nedelcovych M, Dash RP, Tenora L, Zimmermann SC, Gadiano AJ, Garrett C, Alt J, Hollinger KR, Pommier E, Jančařík A, Rojas C, Thomas AG, Wu Y, Wozniak K, Majer P, Slusher BS, Rais R. Nedelcovych M, et al. Among authors: gadiano aj. Mol Pharm. 2017 Oct 2;14(10):3248-3257. doi: 10.1021/acs.molpharmaceut.7b00231. Epub 2017 Aug 31. Mol Pharm. 2017. PMID: 28763226 Free PMC article.
Discovery of a para-Acetoxy-benzyl Ester Prodrug of a Hydroxamate-Based Glutamate Carboxypeptidase II Inhibitor as Oral Therapy for Neuropathic Pain.
Rais R, Vávra J, Tichý T, Dash RP, Gadiano AJ, Tenora L, Monincová L, Bařinka C, Alt J, Zimmermann SC, Slusher CE, Wu Y, Wozniak K, Majer P, Tsukamoto T, Slusher BS. Rais R, et al. Among authors: gadiano aj. J Med Chem. 2017 Sep 28;60(18):7799-7809. doi: 10.1021/acs.jmedchem.7b00825. Epub 2017 Sep 18. J Med Chem. 2017. PMID: 28759215 Free PMC article.
Atypical dopamine transporter inhibitors attenuate compulsive-like methamphetamine self-administration in rats.
Tunstall BJ, Ho CP, Cao J, Vendruscolo JCM, Schmeichel BE, Slack RD, Tanda G, Gadiano AJ, Rais R, Slusher BS, Koob GF, Newman AH, Vendruscolo LF. Tunstall BJ, et al. Among authors: gadiano aj. Neuropharmacology. 2018 Mar 15;131:96-103. doi: 10.1016/j.neuropharm.2017.12.006. Epub 2017 Dec 5. Neuropharmacology. 2018. PMID: 29217282 Free PMC article.
N-Substituted Prodrugs of Mebendazole Provide Improved Aqueous Solubility and Oral Bioavailability in Mice and Dogs.
Zimmermann SC, Tichý T, Vávra J, Dash RP, Slusher CE, Gadiano AJ, Wu Y, Jančařík A, Tenora L, Monincová L, Prchalová E, Riggins GJ, Majer P, Slusher BS, Rais R. Zimmermann SC, et al. Among authors: gadiano aj. J Med Chem. 2018 May 10;61(9):3918-3929. doi: 10.1021/acs.jmedchem.7b01792. Epub 2018 Apr 19. J Med Chem. 2018. PMID: 29648826
Ghrelin agonist HM01 attenuates chemotherapy-induced neurotoxicity in rodent models.
Chiorazzi A, Wozniak KM, Rais R, Wu Y, Gadiano AJ, Farah MH, Liu Y, Canta A, Alberti P, Rodriguez-Menendez V, Meregalli C, Fumagalli G, Monza L, Pozzi E, Vornov JJ, Polydefkis M, Pietra C, Slusher BS, Cavaletti G. Chiorazzi A, et al. Among authors: gadiano aj. Eur J Pharmacol. 2018 Dec 5;840:89-103. doi: 10.1016/j.ejphar.2018.09.029. Epub 2018 Sep 27. Eur J Pharmacol. 2018. PMID: 30268665