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Technological challenges and milestones for writing genomes.
Ostrov N, Beal J, Ellis T, Gordon DB, Karas BJ, Lee HH, Lenaghan SC, Schloss JA, Stracquadanio G, Trefzer A, Bader JS, Church GM, Coelho CM, Efcavitch JW, Güell M, Mitchell LA, Nielsen AAK, Peck B, Smith AC, Stewart CN Jr, Tekotte H. Ostrov N, et al. Among authors: guell m. Science. 2019 Oct 18;366(6463):310-312. doi: 10.1126/science.aay0339. Science. 2019. PMID: 31624201 Free article. No abstract available.
Design, synthesis, and testing toward a 57-codon genome.
Ostrov N, Landon M, Guell M, Kuznetsov G, Teramoto J, Cervantes N, Zhou M, Singh K, Napolitano MG, Moosburner M, Shrock E, Pruitt BW, Conway N, Goodman DB, Gardner CL, Tyree G, Gonzales A, Wanner BL, Norville JE, Lajoie MJ, Church GM. Ostrov N, et al. Among authors: guell m. Science. 2016 Aug 19;353(6301):819-22. doi: 10.1126/science.aaf3639. Science. 2016. PMID: 27540174
RNA-guided human genome engineering via Cas9.
Mali P, Yang L, Esvelt KM, Aach J, Guell M, DiCarlo JE, Norville JE, Church GM. Mali P, et al. Among authors: guell m. Science. 2013 Feb 15;339(6121):823-6. doi: 10.1126/science.1232033. Epub 2013 Jan 3. Science. 2013. PMID: 23287722 Free PMC article.
Inactivation of porcine endogenous retrovirus in pigs using CRISPR-Cas9.
Niu D, Wei HJ, Lin L, George H, Wang T, Lee IH, Zhao HY, Wang Y, Kan Y, Shrock E, Lesha E, Wang G, Luo Y, Qing Y, Jiao D, Zhao H, Zhou X, Wang S, Wei H, Güell M, Church GM, Yang L. Niu D, et al. Among authors: guell m. Science. 2017 Sep 22;357(6357):1303-1307. doi: 10.1126/science.aan4187. Epub 2017 Aug 10. Science. 2017. PMID: 28798043 Free PMC article.
Genome-wide inactivation of porcine endogenous retroviruses (PERVs).
Yang L, Güell M, Niu D, George H, Lesha E, Grishin D, Aach J, Shrock E, Xu W, Poci J, Cortazio R, Wilkinson RA, Fishman JA, Church G. Yang L, et al. Among authors: guell m. Science. 2015 Nov 27;350(6264):1101-4. doi: 10.1126/science.aad1191. Epub 2015 Oct 11. Science. 2015. PMID: 26456528
Enabling large-scale genome editing at repetitive elements by reducing DNA nicking.
Smith CJ, Castanon O, Said K, Volf V, Khoshakhlagh P, Hornick A, Ferreira R, Wu CT, Güell M, Garg S, Ng AHM, Myllykallio H, Church GM. Smith CJ, et al. Among authors: guell m. Nucleic Acids Res. 2020 May 21;48(9):5183-5195. doi: 10.1093/nar/gkaa239. Nucleic Acids Res. 2020. PMID: 32315033 Free PMC article.
Engineering and optimising deaminase fusions for genome editing.
Yang L, Briggs AW, Chew WL, Mali P, Guell M, Aach J, Goodman DB, Cox D, Kan Y, Lesha E, Soundararajan V, Zhang F, Church G. Yang L, et al. Among authors: guell m. Nat Commun. 2016 Nov 2;7:13330. doi: 10.1038/ncomms13330. Nat Commun. 2016. PMID: 27804970 Free PMC article.
91 results