Götz A - Search Results

1

Modulating Hinge Flexibility in the APP Transmembrane Domain Alters γ-Secretase Cleavage.

Götz A, Mylonas N, Högel P, Silber M, Heinel H, Menig S, Vogel A, Feyrer H, Huster D, Luy B, Langosch D, Scharnagl C, Muhle-Goll C, Kamp F, Steiner H. Götz A, et al. Biophys J. 2019 Jun 4;116(11):2103-2120. doi: 10.1016/j.bpj.2019.04.030. Epub 2019 May 3. Biophys J. 2019. PMID: 31130234 Free PMC article.

2

The cleavage domain of the amyloid precursor protein transmembrane helix does not exhibit above-average backbone dynamics.

Pester O, Götz A, Multhaup G, Scharnagl C, Langosch D. Pester O, et al. Among authors: gotz a. Chembiochem. 2013 Oct 11;14(15):1943-8. doi: 10.1002/cbic.201300322. Epub 2013 Sep 17. Chembiochem. 2013. PMID: 24115334

3

Side-chain to main-chain hydrogen bonding controls the intrinsic backbone dynamics of the amyloid precursor protein transmembrane helix.

Scharnagl C, Pester O, Hornburg P, Hornburg D, Götz A, Langosch D. Scharnagl C, et al. Among authors: gotz a. Biophys J. 2014 Mar 18;106(6):1318-26. doi: 10.1016/j.bpj.2014.02.013. Biophys J. 2014. PMID: 24655507 Free PMC article.

4

Glycine Perturbs Local and Global Conformational Flexibility of a Transmembrane Helix.

Högel P, Götz A, Kuhne F, Ebert M, Stelzer W, Rand KD, Scharnagl C, Langosch D. Högel P, et al. Among authors: gotz a. Biochemistry. 2018 Feb 27;57(8):1326-1337. doi: 10.1021/acs.biochem.7b01197. Epub 2018 Feb 9. Biochemistry. 2018. PMID: 29389107

5

Dissecting conformational changes in APP's transmembrane domain linked to ε-efficiency in familial Alzheimer's disease.

Götz A, Scharnagl C. Götz A, et al. PLoS One. 2018 Jul 2;13(7):e0200077. doi: 10.1371/journal.pone.0200077. eCollection 2018. PLoS One. 2018. PMID: 29966005 Free PMC article.

6

Increased H-Bond Stability Relates to Altered ε-Cleavage Efficiency and Aβ Levels in the I45T Familial Alzheimer's Disease Mutant of APP.

Götz A, Högel P, Silber M, Chaitoglou I, Luy B, Muhle-Goll C, Scharnagl C, Langosch D. Götz A, et al. Sci Rep. 2019 Mar 29;9(1):5321. doi: 10.1038/s41598-019-41766-1. Sci Rep. 2019. PMID: 30926830 Free PMC article.

7

The dynamics of γ-secretase and its substrates.

Hitzenberger M, Götz A, Menig S, Brunschweiger B, Zacharias M, Scharnagl C. Hitzenberger M, et al. Among authors: gotz a. Semin Cell Dev Biol. 2020 Sep;105:86-101. doi: 10.1016/j.semcdb.2020.04.008. Epub 2020 May 16. Semin Cell Dev Biol. 2020. PMID: 32423851 Review.

8

Non-canonical Shedding of TNFα by SPPL2a Is Determined by the Conformational Flexibility of Its Transmembrane Helix.

Spitz C, Schlosser C, Guschtschin-Schmidt N, Stelzer W, Menig S, Götz A, Haug-Kröper M, Scharnagl C, Langosch D, Muhle-Goll C, Fluhrer R. Spitz C, et al. Among authors: gotz a. iScience. 2020 Nov 5;23(12):101775. doi: 10.1016/j.isci.2020.101775. eCollection 2020 Dec 18. iScience. 2020. PMID: 33294784 Free PMC article.

9

Influence of denaturation and aggregation of β-lactoglobulin on its tryptic hydrolysis and the release of functional peptides.

Leeb E, Götz A, Letzel T, Cheison SC, Kulozik U. Leeb E, et al. Among authors: gotz a. Food Chem. 2015 Nov 15;187:545-54. doi: 10.1016/j.foodchem.2015.04.034. Epub 2015 Apr 21. Food Chem. 2015. PMID: 25977062

10

Standardized, systemic phenotypic analysis of Umod(C93F) and Umod(A227T) mutant mice.

Kemter E, Prückl P, Rathkolb B, Micklich K, Adler T, Becker L, Beckers J, Busch DH, Götz AA, Hans W, Horsch M, Ivandic B, Klingenspor M, Klopstock T, Rozman J, Schrewe A, Schulz H, Fuchs H, Gailus-Durner V, Hrabé de Angelis M, Wolf E, Aigner B. Kemter E, et al. Among authors: gotz aa. PLoS One. 2013 Oct 24;8(10):e78337. doi: 10.1371/journal.pone.0078337. eCollection 2013. PLoS One. 2013. PMID: 24205203 Free PMC article.

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