Gómez-Cañas M - Search Results

1

Identification of Novel GPR55 Modulators Using Cell-Impedance-Based Label-Free Technology.

Morales P, Whyte LS, Chicharro R, Gómez-Cañas M, Pazos MR, Goya P, Irving AJ, Fernández-Ruiz J, Ross RA, Jagerovic N. Morales P, et al. J Med Chem. 2016 Mar 10;59(5):1840-53. doi: 10.1021/acs.jmedchem.5b01331. Epub 2016 Feb 5. J Med Chem. 2016. PMID: 26789378

2

Novel antiobesity agents: synthesis and pharmacological evaluation of analogues of Rimonabant and of LH21.

Alvarado M, Decara J, Luque MJ, Hernandez-Folgado L, Gómez-Cañas M, Gómez-Ruiz M, Fernández-Ruiz J, Elguero J, Jagerovic N, Serrano A, Goya P, de Fonseca FR. Alvarado M, et al. Bioorg Med Chem. 2013 Apr 1;21(7):1708-16. doi: 10.1016/j.bmc.2013.01.055. Epub 2013 Feb 4. Bioorg Med Chem. 2013. PMID: 23434135

3

Synthetic cannabinoid quinones: preparation, in vitro antiproliferative effects and in vivo prostate antitumor activity.

Morales P, Vara D, Goméz-Cañas M, Zúñiga MC, Olea-Azar C, Goya P, Fernández-Ruiz J, Díaz-Laviada I, Jagerovic N. Morales P, et al. Eur J Med Chem. 2013;70:111-9. doi: 10.1016/j.ejmech.2013.09.043. Epub 2013 Oct 2. Eur J Med Chem. 2013. PMID: 24141201

4

Targeting CB2-GPR55 receptor heteromers modulates cancer cell signaling.

Moreno E, Andradas C, Medrano M, Caffarel MM, Pérez-Gómez E, Blasco-Benito S, Gómez-Cañas M, Pazos MR, Irving AJ, Lluís C, Canela EI, Fernández-Ruiz J, Guzmán M, McCormick PJ, Sánchez C. Moreno E, et al. J Biol Chem. 2014 Aug 8;289(32):21960-72. doi: 10.1074/jbc.M114.561761. Epub 2014 Jun 18. J Biol Chem. 2014. PMID: 24942731 Free PMC article.

5

Selective, nontoxic CB(2) cannabinoid o-quinone with in vivo activity against triple-negative breast cancer.

Morales P, Blasco-Benito S, Andradas C, Gómez-Cañas M, Flores JM, Goya P, Fernández-Ruiz J, Sánchez C, Jagerovic N. Morales P, et al. J Med Chem. 2015 Mar 12;58(5):2256-64. doi: 10.1021/acs.jmedchem.5b00078. Epub 2015 Feb 20. J Med Chem. 2015. PMID: 25671648

6

Synthesis, pharmacological evaluation and docking studies of pyrrole structure-based CB2 receptor antagonists.

Ragusa G, Gómez-Cañas M, Morales P, Hurst DP, Deligia F, Pazos R, Pinna GA, Fernández-Ruiz J, Goya P, Reggio PH, Jagerovic N, García-Arencibia M, Murineddu G. Ragusa G, et al. Eur J Med Chem. 2015 Aug 28;101:651-67. doi: 10.1016/j.ejmech.2015.06.057. Epub 2015 Jul 15. Eur J Med Chem. 2015. PMID: 26209834

7

Tricyclic pyrazoles. Part 8. Synthesis, biological evaluation and modelling of tricyclic pyrazole carboxamides as potential CB2 receptor ligands with antagonist/inverse agonist properties.

Deiana V, Gómez-Cañas M, Pazos MR, Fernández-Ruiz J, Asproni B, Cichero E, Fossa P, Muñoz E, Deligia F, Murineddu G, García-Arencibia M, Pinna GA. Deiana V, et al. Eur J Med Chem. 2016 Apr 13;112:66-80. doi: 10.1016/j.ejmech.2016.02.005. Epub 2016 Feb 6. Eur J Med Chem. 2016. PMID: 26890113

8

Chromenopyrazole, a Versatile Cannabinoid Scaffold with in Vivo Activity in a Model of Multiple Sclerosis.

Morales P, Gómez-Cañas M, Navarro G, Hurst DP, Carrillo-Salinas FJ, Lagartera L, Pazos R, Goya P, Reggio PH, Guaza C, Franco R, Fernández-Ruiz J, Jagerovic N. Morales P, et al. J Med Chem. 2016 Jul 28;59(14):6753-6771. doi: 10.1021/acs.jmedchem.6b00397. Epub 2016 Jul 6. J Med Chem. 2016. PMID: 27309150 Free PMC article.

9

New pyridazinone-4-carboxamides as new cannabinoid receptor type-2 inverse agonists: Synthesis, pharmacological data and molecular docking.

Ragusa G, Gómez-Cañas M, Morales P, Rodríguez-Cueto C, Pazos MR, Asproni B, Cichero E, Fossa P, Pinna GA, Jagerovic N, Fernández-Ruiz J, Murineddu G. Ragusa G, et al. Eur J Med Chem. 2017 Feb 15;127:398-412. doi: 10.1016/j.ejmech.2017.01.002. Epub 2017 Jan 4. Eur J Med Chem. 2017. PMID: 28088085

10

Novel sulfenamides and sulfonamides based on pyridazinone and pyridazine scaffolds as CB₁ receptor ligand antagonists.

Murineddu G, Deligia F, Ragusa G, García-Toscano L, Gómez-Cañas M, Asproni B, Satta V, Cichero E, Pazos R, Fossa P, Loriga G, Fernández-Ruiz J, Pinna GA. Murineddu G, et al. Bioorg Med Chem. 2018 Jan 1;26(1):295-307. doi: 10.1016/j.bmc.2017.11.051. Epub 2017 Dec 2. Bioorg Med Chem. 2018. PMID: 29229226

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