In situ targeting of dendritic cells sets tolerogenic environment and ameliorates CD4+ T-cell response in the postischemic liver.
Funken D, Ishikawa-Ankerhold H, Uhl B, Lerchenberger M, Rentsch M, Mayr D, Massberg S, Werner J, Khandoga A.
Funken D, et al.
FASEB J. 2017 Nov;31(11):4796-4808. doi: 10.1096/fj.201601358R. Epub 2017 Jul 18.
FASEB J. 2017.
PMID: 28720647
Tolerogenic DCs were generated in situ by pretreatment of animals with the vitamin D analog paricalcitol. A mAb-CD44 was used for blockade of CD4(+) T-cell-DC interactions. ...Thus, hepatic DCs are strongly involved in the promotion of CD4(+) T-cell-dependent postischemic …
Tolerogenic DCs were generated in situ by pretreatment of animals with the vitamin D analog paricalcitol. A mAb-CD44 was used for blo …