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Page 1
Chronic Dicer1 deficiency promotes atrophic and neovascular outer retinal pathologies in mice.
Wright CB, Uehara H, Kim Y, Yasuma T, Yasuma R, Hirahara S, Makin RD, Apicella I, Pereira F, Nagasaka Y, Narendran S, Fukuda S, Albuquerque R, Fowler BJ, Bastos-Carvalho A, Georgel P, Hatada I, Chang B, Kerur N, Ambati BK, Ambati J, Gelfand BD. Wright CB, et al. Among authors: fukuda s. Proc Natl Acad Sci U S A. 2020 Feb 4;117(5):2579-2587. doi: 10.1073/pnas.1909761117. Epub 2020 Jan 21. Proc Natl Acad Sci U S A. 2020. PMID: 31964819 Free PMC article.
cGAS drives noncanonical-inflammasome activation in age-related macular degeneration.
Kerur N, Fukuda S, Banerjee D, Kim Y, Fu D, Apicella I, Varshney A, Yasuma R, Fowler BJ, Baghdasaryan E, Marion KM, Huang X, Yasuma T, Hirano Y, Serbulea V, Ambati M, Ambati VL, Kajiwara Y, Ambati K, Hirahara S, Bastos-Carvalho A, Ogura Y, Terasaki H, Oshika T, Kim KB, Hinton DR, Leitinger N, Cambier JC, Buxbaum JD, Kenney MC, Jazwinski SM, Nagai H, Hara I, West AP, Fitzgerald KA, Sadda SR, Gelfand BD, Ambati J. Kerur N, et al. Among authors: fukuda s. Nat Med. 2018 Jan;24(1):50-61. doi: 10.1038/nm.4450. Epub 2017 Nov 27. Nat Med. 2018. PMID: 29176737 Free PMC article.
Repurposing anti-inflammasome NRTIs for improving insulin sensitivity and reducing type 2 diabetes development.
Ambati J, Magagnoli J, Leung H, Wang SB, Andrews CA, Fu D, Pandey A, Sahu S, Narendran S, Hirahara S, Fukuda S, Sun J, Pandya L, Ambati M, Pereira F, Varshney A, Cummings T, Hardin JW, Edun B, Bennett CL, Ambati K, Fowler BJ, Kerur N, Röver C, Leitinger N, Werner BC, Stein JD, Sutton SS, Gelfand BD. Ambati J, et al. Among authors: fukuda s. Nat Commun. 2020 Sep 23;11(1):4737. doi: 10.1038/s41467-020-18528-z. Nat Commun. 2020. PMID: 32968070 Free PMC article.
Cytoplasmic synthesis of endogenous Alu complementary DNA via reverse transcription and implications in age-related macular degeneration.
Fukuda S, Varshney A, Fowler BJ, Wang SB, Narendran S, Ambati K, Yasuma T, Magagnoli J, Leung H, Hirahara S, Nagasaka Y, Yasuma R, Apicella I, Pereira F, Makin RD, Magner E, Liu X, Sun J, Wang M, Baker K, Marion KM, Huang X, Baghdasaryan E, Ambati M, Ambati VL, Pandey A, Pandya L, Cummings T, Banerjee D, Huang P, Yerramothu P, Tolstonog GV, Held U, Erwin JA, Paquola ACM, Herdy JR, Ogura Y, Terasaki H, Oshika T, Darwish S, Singh RK, Mozaffari S, Bhattarai D, Kim KB, Hardin JW, Bennett CL, Hinton DR, Hanson TE, Röver C, Parang K, Kerur N, Liu J, Werner BC, Sutton SS, Sadda SR, Schumann GG, Gelfand BD, Gage FH, Ambati J. Fukuda S, et al. Proc Natl Acad Sci U S A. 2021 Feb 9;118(6):e2022751118. doi: 10.1073/pnas.2022751118. Proc Natl Acad Sci U S A. 2021. PMID: 33526699 Free PMC article.
Nucleoside reverse transcriptase inhibitors and Kamuvudines inhibit amyloid-β induced retinal pigmented epithelium degeneration.
Narendran S, Pereira F, Yerramothu P, Apicella I, Wang SB, Ambati K, Hirahara S, Kim Y, Ambati M, Ambati VL, Huang P, Varshney A, Nagasaka Y, Fukuda S, Baker KL, Marion KM, Deussing JM, Sadda SR, Gelfand BD, Ambati J. Narendran S, et al. Among authors: fukuda s. Signal Transduct Target Ther. 2021 Apr 14;6(1):149. doi: 10.1038/s41392-021-00537-z. Signal Transduct Target Ther. 2021. PMID: 33850097 Free PMC article.
Alu complementary DNA is enriched in atrophic macular degeneration and triggers retinal pigmented epithelium toxicity via cytosolic innate immunity.
Fukuda S, Narendran S, Varshney A, Nagasaka Y, Wang SB, Ambati K, Apicella I, Pereira F, Fowler BJ, Yasuma T, Hirahara S, Yasuma R, Huang P, Yerramothu P, Makin RD, Wang M, Baker KL, Marion KM, Huang X, Baghdasaryan E, Ambati M, Ambati VL, Banerjee D, Bonilha VL, Tolstonog GV, Held U, Ogura Y, Terasaki H, Oshika T, Bhattarai D, Kim KB, Feldman SH, Aguirre JI, Hinton DR, Kerur N, Sadda SR, Schumann GG, Gelfand BD, Ambati J. Fukuda S, et al. Sci Adv. 2021 Oct;7(40):eabj3658. doi: 10.1126/sciadv.abj3658. Epub 2021 Sep 29. Sci Adv. 2021. PMID: 34586848 Free PMC article.
Subretinal injection in mice to study retinal physiology and disease.
Huang P, Narendran S, Pereira F, Fukuda S, Nagasaka Y, Apicella I, Yerramothu P, Marion KM, Cai X, Sadda SR, Gelfand BD, Ambati J. Huang P, et al. Among authors: fukuda s. Nat Protoc. 2022 Jun;17(6):1468-1485. doi: 10.1038/s41596-022-00689-4. Epub 2022 Apr 13. Nat Protoc. 2022. PMID: 35418688 Review.
2,930 results