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The oncogene KRAS promotes cancer cell dissemination by stabilizing spheroid formation via the MEK pathway.
Ogishima J, Taguchi A, Kawata A, Kawana K, Yoshida M, Yoshimatsu Y, Sato M, Nakamura H, Kawata Y, Nishijima A, Fujimoto A, Tomio K, Adachi K, Nagamatsu T, Oda K, Kiyono T, Osuga Y, Fujii T. Ogishima J, et al. Among authors: fujimoto a. BMC Cancer. 2018 Dec 3;18(1):1201. doi: 10.1186/s12885-018-4922-4. BMC Cancer. 2018. PMID: 30509235 Free PMC article.
Spheroid cancer stem cells display reprogrammed metabolism and obtain energy by actively running the tricarboxylic acid (TCA) cycle.
Sato M, Kawana K, Adachi K, Fujimoto A, Yoshida M, Nakamura H, Nishida H, Inoue T, Taguchi A, Takahashi J, Eguchi S, Yamashita A, Tomio K, Wada-Hiraike O, Oda K, Nagamatsu T, Osuga Y, Fujii T. Sato M, et al. Among authors: fujimoto a. Oncotarget. 2016 May 31;7(22):33297-305. doi: 10.18632/oncotarget.8947. Oncotarget. 2016. PMID: 27120812 Free PMC article.
Modification of the Tumor Microenvironment in KRAS or c-MYC-Induced Ovarian Cancer-Associated Peritonitis.
Yoshida M, Taguchi A, Kawana K, Adachi K, Kawata A, Ogishima J, Nakamura H, Fujimoto A, Sato M, Inoue T, Nishida H, Furuya H, Tomio K, Arimoto T, Koga K, Wada-Hiraike O, Oda K, Nagamatsu T, Kiyono T, Osuga Y, Fujii T. Yoshida M, et al. Among authors: fujimoto a. PLoS One. 2016 Aug 2;11(8):e0160330. doi: 10.1371/journal.pone.0160330. eCollection 2016. PLoS One. 2016. PMID: 27483433 Free PMC article.
Expression of Par3 polarity protein correlates with poor prognosis in ovarian cancer.
Nakamura H, Nagasaka K, Kawana K, Taguchi A, Uehara Y, Yoshida M, Sato M, Nishida H, Fujimoto A, Inoue T, Adachi K, Nagamatsu T, Arimoto T, Oda K, Osuga Y, Fujii T. Nakamura H, et al. Among authors: fujimoto a. BMC Cancer. 2016 Nov 17;16(1):897. doi: 10.1186/s12885-016-2929-2. BMC Cancer. 2016. PMID: 27855669 Free PMC article.
Targeting glutamine metabolism and the focal adhesion kinase additively inhibits the mammalian target of the rapamycin pathway in spheroid cancer stem-like properties of ovarian clear cell carcinoma in vitro.
Sato M, Kawana K, Adachi K, Fujimoto A, Yoshida M, Nakamura H, Nishida H, Inoue T, Taguchi A, Ogishima J, Eguchi S, Yamashita A, Tomio K, Wada-Hiraike O, Oda K, Nagamatsu T, Osuga Y, Fujii T. Sato M, et al. Among authors: fujimoto a. Int J Oncol. 2017 Apr;50(4):1431-1438. doi: 10.3892/ijo.2017.3891. Epub 2017 Feb 23. Int J Oncol. 2017. PMID: 28259988
Intraperitoneal neutrophils activated by KRAS-induced ovarian cancer exert antitumor effects by modulating adaptive immunity.
Yoshida M, Taguchi A, Kawana K, Ogishima J, Adachi K, Kawata A, Nakamura H, Sato M, Fujimoto A, Inoue T, Tomio K, Mori M, Nagamatsu T, Arimoto T, Koga K, Hiraike OW, Oda K, Kiyono T, Osuga Y, Fujii T. Yoshida M, et al. Among authors: fujimoto a. Int J Oncol. 2018 Oct;53(4):1580-1590. doi: 10.3892/ijo.2018.4504. Epub 2018 Jul 26. Int J Oncol. 2018. PMID: 30066851 Free PMC article.
Resveratrol Protects Against Pathological Preterm Birth by Suppression of Macrophage-Mediated Inflammation.
Furuya H, Taguchi A, Kawana K, Yamashita A, Inoue E, Yoshida M, Nakamura H, Fujimoto A, Inoue T, Sato M, Nishida H, Nagasaka K, Adachi K, Hoya M, Nagamatsu T, Wada-Hiraike O, Yamashita T, Osuga Y, Fujii T. Furuya H, et al. Among authors: fujimoto a. Reprod Sci. 2015 Dec;22(12):1561-8. doi: 10.1177/1933719115589413. Epub 2015 Jun 2. Reprod Sci. 2015. PMID: 26037299
Decreased expression of the plasminogen activator inhibitor type 1 is involved in degradation of extracellular matrix surrounding cervical cancer stem cells.
Sato M, Kawana K, Adachi K, Fujimoto A, Yoshida M, Nakamura H, Nishida H, Inoue T, Taguchi A, Takahashi J, Kojima S, Yamashita A, Tomio K, Nagamatsu T, Wada-Hiraike O, Oda K, Osuga Y, Fujii T. Sato M, et al. Among authors: fujimoto a. Int J Oncol. 2016 Feb;48(2):829-35. doi: 10.3892/ijo.2015.3283. Epub 2015 Dec 9. Int J Oncol. 2016. PMID: 26676222
Systemic delivery of siRNA by actively targeted polyion complex micelles for silencing the E6 and E7 human papillomavirus oncogenes.
Nishida H, Matsumoto Y, Kawana K, Christie RJ, Naito M, Kim BS, Toh K, Min HS, Yi Y, Matsumoto Y, Kim HJ, Miyata K, Taguchi A, Tomio K, Yamashita A, Inoue T, Nakamura H, Fujimoto A, Sato M, Yoshida M, Adachi K, Arimoto T, Wada-Hiraike O, Oda K, Nagamatsu T, Nishiyama N, Kataoka K, Osuga Y, Fujii T. Nishida H, et al. Among authors: fujimoto a. J Control Release. 2016 Jun 10;231:29-37. doi: 10.1016/j.jconrel.2016.03.016. Epub 2016 Mar 12. J Control Release. 2016. PMID: 26979870
880 results