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Page 1
Propafenone blocks human cardiac Kir2.x channels by decreasing the negative electrostatic charge in the cytoplasmic pore.
Amorós I, Dolz-Gaitón P, Gómez R, Matamoros M, Barana A, de la Fuente MG, Núñez M, Pérez-Hernández M, Moraleda I, Gálvez E, Iriepa I, Tamargo J, Caballero R, Delpón E. Amorós I, et al. Among authors: de la fuente mg. Biochem Pharmacol. 2013 Jul 15;86(2):267-78. doi: 10.1016/j.bcp.2013.04.023. Epub 2013 May 3. Biochem Pharmacol. 2013. PMID: 23648307
p.D1690N Nav1.5 rescues p.G1748D mutation gating defects in a compound heterozygous Brugada syndrome patient.
Núñez L, Barana A, Amorós I, de la Fuente MG, Dolz-Gaitón P, Gómez R, Rodríguez-García I, Mosquera I, Monserrat L, Delpón E, Caballero R, Castro-Beiras A, Tamargo J. Núñez L, et al. Among authors: de la fuente mg. Heart Rhythm. 2013 Feb;10(2):264-72. doi: 10.1016/j.hrthm.2012.10.025. Epub 2012 Oct 18. Heart Rhythm. 2013. PMID: 23085483
Functional effects of a missense mutation in HERG associated with type 2 long QT syndrome.
Amorós I, Jiménez-Jáimez J, Tercedor L, Barana A, Gómez R, de la Fuente MG, Dolz-Gaitón P, Alvarez M, Martínez-Espín E, Lorente JA, Melgares R, Tamargo J, Delpón E, Caballero R. Amorós I, et al. Among authors: de la fuente mg. Heart Rhythm. 2011 Mar;8(3):463-70. doi: 10.1016/j.hrthm.2010.11.032. Epub 2010 Nov 23. Heart Rhythm. 2011. PMID: 21109023
In humans, chronic atrial fibrillation decreases the transient outward current and ultrarapid component of the delayed rectifier current differentially on each atria and increases the slow component of the delayed rectifier current in both.
Caballero R, de la Fuente MG, Gómez R, Barana A, Amorós I, Dolz-Gaitón P, Osuna L, Almendral J, Atienza F, Fernández-Avilés F, Pita A, Rodríguez-Roda J, Pinto A, Tamargo J, Delpón E. Caballero R, et al. Among authors: de la fuente mg. J Am Coll Cardiol. 2010 May 25;55(21):2346-54. doi: 10.1016/j.jacc.2010.02.028. J Am Coll Cardiol. 2010. PMID: 20488306 Free article.