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Novel N-aryl nicotinamide derivatives: Taking stock on 3,6-diazabicyclo[3.1.1]heptanes as ligands for neuronal acetylcholine receptors.
Murineddu G, Gotti C, Asproni B, Corona P, Martinello K, Plutino S, Fucile S, Temml V, Moretti M, Viani P, Schuster D, Piras S, Deligia F, Pinna GA. Murineddu G, et al. Among authors: fucile s. Eur J Med Chem. 2019 Oct 15;180:51-61. doi: 10.1016/j.ejmech.2019.06.079. Epub 2019 Jul 5. Eur J Med Chem. 2019. PMID: 31299587 Free article.
GABA(A)-current rundown of temporal lobe epilepsy is associated with repetitive activation of GABA(A) "phasic" receptors.
Palma E, Roseti C, Maiolino F, Fucile S, Martinello K, Mazzuferi M, Aronica E, Manfredi M, Esposito V, Cantore G, Miledi R, Simonato M, Eusebi F. Palma E, et al. Among authors: fucile s. Proc Natl Acad Sci U S A. 2007 Dec 26;104(52):20944-8. doi: 10.1073/pnas.0710522105. Epub 2007 Dec 14. Proc Natl Acad Sci U S A. 2007. PMID: 18083839 Free PMC article.
Adenosine receptor antagonists alter the stability of human epileptic GABAA receptors.
Roseti C, Martinello K, Fucile S, Piccari V, Mascia A, Di Gennaro G, Quarato PP, Manfredi M, Esposito V, Cantore G, Arcella A, Simonato M, Fredholm BB, Limatola C, Miledi R, Eusebi F. Roseti C, et al. Among authors: fucile s. Proc Natl Acad Sci U S A. 2008 Sep 30;105(39):15118-23. doi: 10.1073/pnas.0807277105. Epub 2008 Sep 22. Proc Natl Acad Sci U S A. 2008. PMID: 18809912 Free PMC article.
Design, synthesis, and pharmacological characterization of novel spirocyclic quinuclidinyl-Δ2-isoxazoline derivatives as potent and selective agonists of α7 nicotinic acetylcholine receptors.
Dallanoce C, Magrone P, Matera C, Frigerio F, Grazioso G, De Amici M, Fucile S, Piccari V, Frydenvang K, Pucci L, Gotti C, Clementi F, De Micheli C. Dallanoce C, et al. Among authors: fucile s. ChemMedChem. 2011 May 2;6(5):889-903. doi: 10.1002/cmdc.201000514. Epub 2011 Mar 1. ChemMedChem. 2011. PMID: 21365765
PI3Kγ inhibition reduces blood pressure by a vasorelaxant Akt/L-type calcium channel mechanism.
Carnevale D, Vecchione C, Mascio G, Esposito G, Cifelli G, Martinello K, Landolfi A, Selvetella G, Grieco P, Damato A, Franco E, Haase H, Maffei A, Ciraolo E, Fucile S, Frati G, Mazzoni O, Hirsch E, Lembo G. Carnevale D, et al. Among authors: fucile s. Cardiovasc Res. 2012 Jan 1;93(1):200-9. doi: 10.1093/cvr/cvr288. Epub 2011 Oct 27. Cardiovasc Res. 2012. PMID: 22038741
CC4, a dimer of cytisine, is a selective partial agonist at α4β2/α6β2 nAChR with improved selectivity for tobacco smoking cessation.
Sala M, Braida D, Pucci L, Manfredi I, Marks MJ, Wageman CR, Grady SR, Loi B, Fucile S, Fasoli F, Zoli M, Tasso B, Sparatore F, Clementi F, Gotti C. Sala M, et al. Among authors: fucile s. Br J Pharmacol. 2013 Feb;168(4):835-49. doi: 10.1111/j.1476-5381.2012.02204.x. Br J Pharmacol. 2013. PMID: 22957729 Free PMC article.
146 results