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Disrupting Roquin-1 interaction with Regnase-1 induces autoimmunity and enhances antitumor responses.
Behrens G, Edelmann SL, Raj T, Kronbeck N, Monecke T, Davydova E, Wong EH, Kifinger L, Giesert F, Kirmaier ME, Hohn C, de Jonge LS, Pisfil MG, Fu M, Theurich S, Feske S, Kawakami N, Wurst W, Niessing D, Heissmeyer V. Behrens G, et al. Among authors: fu m. Nat Immunol. 2021 Dec;22(12):1563-1576. doi: 10.1038/s41590-021-01064-3. Epub 2021 Nov 22. Nat Immunol. 2021. PMID: 34811541 Free PMC article.
Cleavage of roquin and regnase-1 by the paracaspase MALT1 releases their cooperatively repressed targets to promote T(H)17 differentiation.
Jeltsch KM, Hu D, Brenner S, Zöller J, Heinz GA, Nagel D, Vogel KU, Rehage N, Warth SC, Edelmann SL, Gloury R, Martin N, Lohs C, Lech M, Stehklein JE, Geerlof A, Kremmer E, Weber A, Anders HJ, Schmitz I, Schmidt-Supprian M, Fu M, Holtmann H, Krappmann D, Ruland J, Kallies A, Heikenwalder M, Heissmeyer V. Jeltsch KM, et al. Among authors: fu m. Nat Immunol. 2014 Nov;15(11):1079-89. doi: 10.1038/ni.3008. Epub 2014 Oct 5. Nat Immunol. 2014. PMID: 25282160
Regnase-1 is essential for B cell homeostasis to prevent immunopathology.
Bhat N, Virgen-Slane R, Ramezani-Rad P, Leung CR, Chen C, Balsells D, Shukla A, Kao E, Apgar JR, Fu M, Ware CF, Rickert RC. Bhat N, et al. Among authors: fu m. J Exp Med. 2021 May 3;218(5):e20200971. doi: 10.1084/jem.20200971. J Exp Med. 2021. PMID: 33822844 Free PMC article.
Targeted disruption of MCPIP1/Zc3h12a results in fatal inflammatory disease.
Miao R, Huang S, Zhou Z, Quinn T, Van Treeck B, Nayyar T, Dim D, Jiang Z, Papasian CJ, Eugene Chen Y, Liu G, Fu M. Miao R, et al. Among authors: fu m. Immunol Cell Biol. 2013 May;91(5):368-76. doi: 10.1038/icb.2013.11. Epub 2013 Apr 9. Immunol Cell Biol. 2013. PMID: 23567898 Free PMC article.
4,401 results