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Synthesis and preliminary evaluation of novel 11C-labeled GluN2B-selective NMDA receptor negative allosteric modulators.
Sun JY, Kumata K, Chen Z, Zhang YD, Chen JH, Hatori A, Fu HL, Rong J, Deng XY, Yamasaki T, Xie L, Hu K, Fujinaga M, Yu QZ, Shao T, Collier TL, Josephson L, Shao YH, Du YF, Wang L, Xu H, Zhang MR, Liang SH. Sun JY, et al. Among authors: fu hl. Acta Pharmacol Sin. 2021 Mar;42(3):491-498. doi: 10.1038/s41401-020-0456-9. Epub 2020 Jul 13. Acta Pharmacol Sin. 2021. PMID: 32661351 Free PMC article.
Positron Emission Tomography (PET) Ligand Development for Ionotropic Glutamate Receptors: Challenges and Opportunities for Radiotracer Targeting N-Methyl-d-aspartate (NMDA), α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA), and Kainate Receptors.
Fu H, Chen Z, Josephson L, Li Z, Liang SH. Fu H, et al. J Med Chem. 2019 Jan 24;62(2):403-419. doi: 10.1021/acs.jmedchem.8b00714. Epub 2018 Aug 27. J Med Chem. 2019. PMID: 30110164 Free PMC article. Review.
Synthesis, pharmacology and preclinical evaluation of 11C-labeled 1,3-dihydro-2H-benzo[d]imidazole-2-ones for imaging γ8-dependent transmembrane AMPA receptor regulatory protein.
Chen Z, Mori W, Zhang X, Yamasaki T, Dunn PJ, Zhang G, Fu H, Shao T, Zhang Y, Hatori A, Ma L, Fujinaga M, Xie L, Deng X, Li H, Yu Q, Rong J, Josephson L, Ma JA, Shao Y, Tomita S, Zhang MR, Liang SH. Chen Z, et al. Eur J Med Chem. 2018 Sep 5;157:898-908. doi: 10.1016/j.ejmech.2018.08.019. Epub 2018 Aug 9. Eur J Med Chem. 2018. PMID: 30145376 Free PMC article.
Synthesis and Preliminary Evaluations of a Triazole-Cored Antagonist as a PET Imaging Probe ([18F]N2B-0518) for GluN2B Subunit in the Brain.
Fu H, Tang W, Chen Z, Belov VV, Zhang G, Shao T, Zhang X, Yu Q, Rong J, Deng X, Han W, Myers SJ, Giffenig P, Wang L, Josephson L, Shao Y, Davenport AT, Daunais JB, Papisov M, Yuan H, Li Z, Traynelis SF, Liang SH. Fu H, et al. ACS Chem Neurosci. 2019 May 15;10(5):2263-2275. doi: 10.1021/acschemneuro.8b00591. Epub 2019 Feb 27. ACS Chem Neurosci. 2019. PMID: 30698943 Free PMC article.
Design, Synthesis, and Evaluation of Reversible and Irreversible Monoacylglycerol Lipase Positron Emission Tomography (PET) Tracers Using a "Tail Switching" Strategy on a Piperazinyl Azetidine Skeleton.
Chen Z, Mori W, Deng X, Cheng R, Ogasawara D, Zhang G, Schafroth MA, Dahl K, Fu H, Hatori A, Shao T, Zhang Y, Yamasaki T, Zhang X, Rong J, Yu Q, Hu K, Fujinaga M, Xie L, Kumata K, Gou Y, Chen J, Gu S, Bao L, Wang L, Collier TL, Vasdev N, Shao Y, Ma JA, Cravatt BF, Fowler C, Josephson L, Zhang MR, Liang SH. Chen Z, et al. J Med Chem. 2019 Apr 11;62(7):3336-3353. doi: 10.1021/acs.jmedchem.8b01778. Epub 2019 Mar 21. J Med Chem. 2019. PMID: 30829483 Free PMC article.
Design, Synthesis, and Evaluation of 18F-Labeled Monoacylglycerol Lipase Inhibitors as Novel Positron Emission Tomography Probes.
Chen Z, Mori W, Fu H, Schafroth MA, Hatori A, Shao T, Zhang G, Van RS, Zhang Y, Hu K, Fujinaga M, Wang L, Belov V, Ogasawara D, Giffenig P, Deng X, Rong J, Yu Q, Zhang X, Papisov MI, Shao Y, Collier TL, Ma JA, Cravatt BF, Josephson L, Zhang MR, Liang SH. Chen Z, et al. J Med Chem. 2019 Oct 10;62(19):8866-8872. doi: 10.1021/acs.jmedchem.9b00936. Epub 2019 Sep 26. J Med Chem. 2019. PMID: 31518130 Free PMC article.
Radiosynthesis and preliminary evaluation of 11C-labeled 4-cyclopropyl-7-(3-methoxyphenoxy)-3,4-dihydro-2H-benzo[e] [1,2,4] thiadiazine 1,1-dioxide for PET imaging AMPA receptors.
Chen J, Gan J, Sun J, Chen Z, Fu H, Rong J, Deng X, Shang J, Gong J, Shao T, Collier L, Wang L, Xu H, Liang SH. Chen J, et al. Tetrahedron Lett. 2020 Mar 19;61(12):151635. doi: 10.1016/j.tetlet.2020.151635. Epub 2020 Jan 17. Tetrahedron Lett. 2020. PMID: 32153306 Free PMC article.
163 results