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The disruption of the CCDC6 - PP4 axis induces a BRCAness like phenotype and sensitivity to PARP inhibitors in high-grade serous ovarian carcinoma.
Morra F, Merolla F, Damia G, Ricci F, Varricchio S, Ilardi G, Arenare L, Califano D, Napolitano V, Fruscio R, Melillo RM, Palazzo L, Celetti A. Morra F, et al. Among authors: fruscio r. J Exp Clin Cancer Res. 2022 Aug 13;41(1):245. doi: 10.1186/s13046-022-02459-2. J Exp Clin Cancer Res. 2022. PMID: 35964058 Free PMC article.
Unique features of the mode of action of ET-743.
D'Incalci M, Erba E, Damia G, Galliera E, Carrassa L, Marchini S, Mantovani R, Tognon G, Fruscio R, Jimeno J, Faircloth GT. D'Incalci M, et al. Among authors: fruscio r. Oncologist. 2002;7(3):210-6. doi: 10.1634/theoncologist.7-3-210. Oncologist. 2002. PMID: 12065793 Free article. Review.
PRL-3 phosphatase is implicated in ovarian cancer growth.
Polato F, Codegoni A, Fruscio R, Perego P, Mangioni C, Saha S, Bardelli A, Broggini M. Polato F, et al. Among authors: fruscio r. Clin Cancer Res. 2005 Oct 1;11(19 Pt 1):6835-9. doi: 10.1158/1078-0432.CCR-04-2357. Clin Cancer Res. 2005. PMID: 16203771
Ovarian carcinoma tumor-initiating cells have a mesenchymal phenotype.
Ricci F, Bernasconi S, Perego P, Ganzinelli M, Russo G, Bono F, Mangioni C, Fruscio R, Signorelli M, Broggini M, Damia G. Ricci F, et al. Among authors: fruscio r. Cell Cycle. 2012 May 15;11(10):1966-76. doi: 10.4161/cc.20308. Epub 2012 May 15. Cell Cycle. 2012. PMID: 22544328
The zinc finger gene ZIC2 has features of an oncogene and its overexpression correlates strongly with the clinical course of epithelial ovarian cancer.
Marchini S, Poynor E, Barakat RR, Clivio L, Cinquini M, Fruscio R, Porcu L, Bussani C, D'Incalci M, Erba E, Romano M, Cattoretti G, Katsaros D, Koff A, Luzzatto L. Marchini S, et al. Among authors: fruscio r. Clin Cancer Res. 2012 Aug 15;18(16):4313-24. doi: 10.1158/1078-0432.CCR-12-0037. Epub 2012 Jun 25. Clin Cancer Res. 2012. PMID: 22733541 Free PMC article.
226 results