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Cellular iron governs the host response to malaria.
Wideman SK, Frost JN, Richter FC, Naylor C, Lopes JM, Viveiros N, Teh MR, Preston AE, White N, Yusuf S, Draper SJ, Armitage AE, Duarte TL, Drakesmith H. Wideman SK, et al. Among authors: frost jn. PLoS Pathog. 2023 Oct 9;19(10):e1011679. doi: 10.1371/journal.ppat.1011679. eCollection 2023 Oct. PLoS Pathog. 2023. PMID: 37812650 Free PMC article.
Hepcidin-Mediated Hypoferremia Disrupts Immune Responses to Vaccination and Infection.
Frost JN, Tan TK, Abbas M, Wideman SK, Bonadonna M, Stoffel NU, Wray K, Kronsteiner B, Smits G, Campagna DR, Duarte TL, Lopes JM, Shah A, Armitage AE, Arezes J, Lim PJ, Preston AE, Ahern D, Teh M, Naylor C, Salio M, Gileadi U, Andrews SC, Dunachie SJ, Zimmermann MB, van der Klis FRM, Cerundolo V, Bannard O, Draper SJ, Townsend ARM, Galy B, Fleming MD, Lewis MC, Drakesmith H. Frost JN, et al. Med. 2021 Feb 12;2(2):164-179.e12. doi: 10.1016/j.medj.2020.10.004. Med. 2021. PMID: 33665641 Free PMC article.
Adaptive immunity and vaccination - iron in the spotlight.
Preston AE, Drakesmith H, Frost JN. Preston AE, et al. Among authors: frost jn. Immunother Adv. 2021 Jun 17;1(1):ltab007. doi: 10.1093/immadv/ltab007. eCollection 2021 Jan. Immunother Adv. 2021. PMID: 35919735 Free PMC article. Review.
Plasma iron controls neutrophil production and function.
Frost JN, Wideman SK, Preston AE, Teh MR, Ai Z, Wang L, Cross A, White N, Yazicioglu Y, Bonadonna M, Clarke AJ, Armitage AE, Galy B, Udalova IA, Drakesmith H. Frost JN, et al. Sci Adv. 2022 Oct 7;8(40):eabq5384. doi: 10.1126/sciadv.abq5384. Epub 2022 Oct 5. Sci Adv. 2022. PMID: 36197985 Free PMC article.
Hepcidin is regulated by promoter-associated histone acetylation and HDAC3.
Pasricha SR, Lim PJ, Duarte TL, Casu C, Oosterhuis D, Mleczko-Sanecka K, Suciu M, Da Silva AR, Al-Hourani K, Arezes J, McHugh K, Gooding S, Frost JN, Wray K, Santos A, Porto G, Repapi E, Gray N, Draper SJ, Ashley N, Soilleux E, Olinga P, Muckenthaler MU, Hughes JR, Rivella S, Milne TA, Armitage AE, Drakesmith H. Pasricha SR, et al. Among authors: frost jn. Nat Commun. 2017 Sep 1;8(1):403. doi: 10.1038/s41467-017-00500-z. Nat Commun. 2017. PMID: 28864822 Free PMC article.
Antibodies against the erythroferrone N-terminal domain prevent hepcidin suppression and ameliorate murine thalassemia.
Arezes J, Foy N, McHugh K, Quinkert D, Benard S, Sawant A, Frost JN, Armitage AE, Pasricha SR, Lim PJ, Tam MS, Lavallie E, Pittman DD, Cunningham O, Lambert M, Murphy JE, Draper SJ, Jasuja R, Drakesmith H. Arezes J, et al. Among authors: frost jn. Blood. 2020 Feb 20;135(8):547-557. doi: 10.1182/blood.2019003140. Blood. 2020. PMID: 31899794 Free PMC article.
The battle for iron in enteric infections.
Sousa Gerós A, Simmons A, Drakesmith H, Aulicino A, Frost JN. Sousa Gerós A, et al. Among authors: frost jn. Immunology. 2020 Nov;161(3):186-199. doi: 10.1111/imm.13236. Epub 2020 Aug 11. Immunology. 2020. PMID: 32639029 Free PMC article. Review.
Evaluation of perturbed iron-homeostasis in a prospective cohort of patients with COVID-19.
Frost JN, Hamilton F, Arnold D, Elvers KT, Shah A, Armitage AE, Milne A, McKernon J, Attwood M, Chen YL, Xue L, Youngs J, Provine NM, Bicanic T, Klenerman P, Drakesmith H, Ghazal P. Frost JN, et al. Wellcome Open Res. 2022 Jun 21;7:173. doi: 10.12688/wellcomeopenres.17904.1. eCollection 2022. Wellcome Open Res. 2022. PMID: 35935705 Free PMC article.
Transcriptomic profiling of the myeloma bone-lining niche reveals BMP signalling inhibition to improve bone disease.
Gooding S, Olechnowicz SWZ, Morris EV, Armitage AE, Arezes J, Frost J, Repapi E, Edwards JR, Ashley N, Waugh C, Gray N, Martinez-Hackert E, Lim PJ, Pasricha SR, Knowles H, Mead AJ, Ramasamy K, Drakesmith H, Edwards CM. Gooding S, et al. Nat Commun. 2019 Oct 4;10(1):4533. doi: 10.1038/s41467-019-12296-1. Nat Commun. 2019. PMID: 31586071 Free PMC article.
24 results