Mature iPSC-derived astrocytes of an ALS/FTD patient carrying the TDP43A90V mutation display a mild reactive state and release polyP toxic to motoneurons.
Rojas F, Aguilar R, Almeida S, Fritz E, Corvalán D, Ampuero E, Abarzúa S, Garcés P, Amaro A, Diaz I, Arredondo C, Cortes N, Sanchez M, Mercado C, Varela-Nallar L, Gao FB, Montecino M, van Zundert B.
Rojas F, et al. Among authors: fritz e.
Front Cell Dev Biol. 2023 Jul 28;11:1226604. doi: 10.3389/fcell.2023.1226604. eCollection 2023.
Front Cell Dev Biol. 2023.
PMID: 37645251
Free PMC article.