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Hydropersulfides inhibit lipid peroxidation and ferroptosis by scavenging radicals.
Barayeu U, Schilling D, Eid M, Xavier da Silva TN, Schlicker L, Mitreska N, Zapp C, Gräter F, Miller AK, Kappl R, Schulze A, Friedmann Angeli JP, Dick TP. Barayeu U, et al. Among authors: friedmann angeli jp. Nat Chem Biol. 2023 Jan;19(1):28-37. doi: 10.1038/s41589-022-01145-w. Epub 2022 Sep 15. Nat Chem Biol. 2023. PMID: 36109647 Free PMC article.
Ferroptosis: The Greasy Side of Cell Death.
Friedmann Angeli JP, Miyamoto S, Schulze A. Friedmann Angeli JP, et al. Chem Res Toxicol. 2019 Mar 18;32(3):362-369. doi: 10.1021/acs.chemrestox.8b00349. Epub 2019 Jan 31. Chem Res Toxicol. 2019. PMID: 30653290 Review.
The integrated stress response effector ATF4 is an obligatory metabolic activator of NRF2.
Kreß JKC, Jessen C, Hufnagel A, Schmitz W, Xavier da Silva TN, Ferreira Dos Santos A, Mosteo L, Goding CR, Friedmann Angeli JP, Meierjohann S. Kreß JKC, et al. Among authors: friedmann angeli jp. Cell Rep. 2023 Jul 25;42(7):112724. doi: 10.1016/j.celrep.2023.112724. Epub 2023 Jul 4. Cell Rep. 2023. PMID: 37410595 Free article.
LRP8-mediated selenocysteine uptake is a targetable vulnerability in MYCN-amplified neuroblastoma.
Alborzinia H, Chen Z, Yildiz U, Freitas FP, Vogel FCE, Varga JP, Batani J, Bartenhagen C, Schmitz W, Büchel G, Michalke B, Zheng J, Meierjohann S, Girardi E, Espinet E, Flórez AF, Dos Santos AF, Aroua N, Cheytan T, Haenlin J, Schlicker L, Xavier da Silva TN, Przybylla A, Zeisberger P, Superti-Furga G, Eilers M, Conrad M, Fabiano M, Schweizer U, Fischer M, Schulze A, Trumpp A, Friedmann Angeli JP. Alborzinia H, et al. Among authors: friedmann angeli jp. EMBO Mol Med. 2023 Aug 7;15(8):e18014. doi: 10.15252/emmm.202318014. Epub 2023 Jul 12. EMBO Mol Med. 2023. PMID: 37435859 Free PMC article.
Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice.
Friedmann Angeli JP, Schneider M, Proneth B, Tyurina YY, Tyurin VA, Hammond VJ, Herbach N, Aichler M, Walch A, Eggenhofer E, Basavarajappa D, Rådmark O, Kobayashi S, Seibt T, Beck H, Neff F, Esposito I, Wanke R, Förster H, Yefremova O, Heinrichmeyer M, Bornkamm GW, Geissler EK, Thomas SB, Stockwell BR, O'Donnell VB, Kagan VE, Schick JA, Conrad M. Friedmann Angeli JP, et al. Nat Cell Biol. 2014 Dec;16(12):1180-91. doi: 10.1038/ncb3064. Epub 2014 Nov 17. Nat Cell Biol. 2014. PMID: 25402683 Free PMC article.
Emerging aspects in the regulation of ferroptosis.
Nehring H, Meierjohann S, Friedmann Angeli JP. Nehring H, et al. Among authors: friedmann angeli jp. Biochem Soc Trans. 2020 Oct 30;48(5):2253-2259. doi: 10.1042/BST20200523. Biochem Soc Trans. 2020. PMID: 33125483 Review.
31 results