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Mirk/Dyrk1b mediates cell survival in rhabdomyosarcomas.
Mercer SE, Ewton DZ, Shah S, Naqvi A, Friedman E. Mercer SE, et al. Among authors: friedman e. Cancer Res. 2006 May 15;66(10):5143-50. doi: 10.1158/0008-5472.CAN-05-1539. Cancer Res. 2006. PMID: 16707437
The cyclin-dependent kinase inhibitor p27Kip1 is stabilized in G(0) by Mirk/dyrk1B kinase.
Deng X, Mercer SE, Shah S, Ewton DZ, Friedman E. Deng X, et al. Among authors: friedman e. J Biol Chem. 2004 May 21;279(21):22498-504. doi: 10.1074/jbc.M400479200. Epub 2004 Mar 9. J Biol Chem. 2004. PMID: 15010468 Free article.
Mitogen stimulation then causes cells to enter G(1), reduces Mirk levels (Deng, X., Ewton, D., Pawlikowski, B., Maimone, M., and Friedman, E. (2003) J. Biol. Chem. 278, 41347-41354), and initiates the translocation of p27 to the cytoplasm. ...
Mitogen stimulation then causes cells to enter G(1), reduces Mirk levels (Deng, X., Ewton, D., Pawlikowski, B., Maimone, M., and Friedman …
Mirk/dyrk1B kinase destabilizes cyclin D1 by phosphorylation at threonine 288.
Zou Y, Ewton DZ, Deng X, Mercer SE, Friedman E. Zou Y, et al. Among authors: friedman e. J Biol Chem. 2004 Jun 25;279(26):27790-8. doi: 10.1074/jbc.M403042200. Epub 2004 Apr 9. J Biol Chem. 2004. PMID: 15075324 Free article.
Destabilization was confirmed by induction of a stable Mirk transfectant of Mv1Lu cells, which blocked cell migration (Zou, Y., Lim, S., Lee, K., Deng, X., and Friedman, E. (2003) J. Biol. Chem. 278, 49573-49581), and caused a decrease in the half-life of endogenous …
Destabilization was confirmed by induction of a stable Mirk transfectant of Mv1Lu cells, which blocked cell migration (Zou, Y., Lim, S., Lee …
Mirk/dyrk1B decreases the nuclear accumulation of class II histone deacetylases during skeletal muscle differentiation.
Deng X, Ewton DZ, Mercer SE, Friedman E. Deng X, et al. Among authors: friedman e. J Biol Chem. 2005 Feb 11;280(6):4894-905. doi: 10.1074/jbc.M411894200. Epub 2004 Nov 16. J Biol Chem. 2005. PMID: 15546868 Free article.
Depletion of endogenous Mirk from C2C12 myoblasts by RNA interference blocks skeletal muscle differentiation (Deng, X., Ewton, D., Pawlikowski, B., Maimone, M., and Friedman, E. (2003) J. Biol. Chem. 278, 41347-41354). We now demonstrate that knockdown of Mirk block …
Depletion of endogenous Mirk from C2C12 myoblasts by RNA interference blocks skeletal muscle differentiation (Deng, X., Ewton, D., Pawlikows …
3,159 results