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Gene targeting using a promoterless gene trap vector ("targeted trapping") is an efficient method to mutate a large fraction of genes.
Friedel RH, Plump A, Lu X, Spilker K, Jolicoeur C, Wong K, Venkatesh TR, Yaron A, Hynes M, Chen B, Okada A, McConnell SK, Rayburn H, Tessier-Lavigne M. Friedel RH, et al. Proc Natl Acad Sci U S A. 2005 Sep 13;102(37):13188-93. doi: 10.1073/pnas.0505474102. Epub 2005 Aug 29. Proc Natl Acad Sci U S A. 2005. PMID: 16129827 Free PMC article.
Plexin-B2 controls the development of cerebellar granule cells.
Friedel RH, Kerjan G, Rayburn H, Schüller U, Sotelo C, Tessier-Lavigne M, Chédotal A. Friedel RH, et al. J Neurosci. 2007 Apr 4;27(14):3921-32. doi: 10.1523/JNEUROSCI.4710-06.2007. J Neurosci. 2007. PMID: 17409257 Free PMC article.
Semaphorin 4C and 4G are ligands of Plexin-B2 required in cerebellar development.
Maier V, Jolicoeur C, Rayburn H, Takegahara N, Kumanogoh A, Kikutani H, Tessier-Lavigne M, Wurst W, Friedel RH. Maier V, et al. Among authors: friedel rh. Mol Cell Neurosci. 2011 Feb;46(2):419-31. doi: 10.1016/j.mcn.2010.11.005. Epub 2010 Nov 29. Mol Cell Neurosci. 2011. PMID: 21122816 Free PMC article.
Semaphorins guide the entry of dendritic cells into the lymphatics by activating myosin II.
Takamatsu H, Takegahara N, Nakagawa Y, Tomura M, Taniguchi M, Friedel RH, Rayburn H, Tessier-Lavigne M, Yoshida Y, Okuno T, Mizui M, Kang S, Nojima S, Tsujimura T, Nakatsuji Y, Katayama I, Toyofuku T, Kikutani H, Kumanogoh A. Takamatsu H, et al. Among authors: friedel rh. Nat Immunol. 2010 Jul;11(7):594-600. doi: 10.1038/ni.1885. Epub 2010 May 30. Nat Immunol. 2010. PMID: 20512151 Free PMC article.
Gene trap mutagenesis in the mouse.
Friedel RH, Soriano P. Friedel RH, et al. Methods Enzymol. 2010;477:243-69. doi: 10.1016/S0076-6879(10)77013-0. Methods Enzymol. 2010. PMID: 20699145 Free PMC article.
Targeting embryonic stem cells.
Friedel RH. Friedel RH. Methods Mol Biol. 2009;561:185-97. doi: 10.1007/978-1-60327-019-9_12. Methods Mol Biol. 2009. PMID: 19504072
A resource of targeted mutant mouse lines for 5,061 genes.
Birling MC, Yoshiki A, Adams DJ, Ayabe S, Beaudet AL, Bottomley J, Bradley A, Brown SDM, Bürger A, Bushell W, Chiani F, Chin HG, Christou S, Codner GF, DeMayo FJ, Dickinson ME, Doe B, Donahue LR, Fray MD, Gambadoro A, Gao X, Gertsenstein M, Gomez-Segura A, Goodwin LO, Heaney JD, Hérault Y, de Angelis MH, Jiang ST, Justice MJ, Kasparek P, King RE, Kühn R, Lee H, Lee YJ, Liu Z, Lloyd KCK, Lorenzo I, Mallon AM, McKerlie C, Meehan TF, Fuentes VM, Newman S, Nutter LMJ, Oh GT, Pavlovic G, Ramirez-Solis R, Rosen B, Ryder EJ, Santos LA, Schick J, Seavitt JR, Sedlacek R, Seisenberger C, Seong JK, Skarnes WC, Sorg T, Steel KP, Tamura M, Tocchini-Valentini GP, Wang CL, Wardle-Jones H, Wattenhofer-Donzé M, Wells S, Wiles MV, Willis BJ, Wood JA, Wurst W, Xu Y; International Mouse Phenotyping Consortium (IMPC); Teboul L, Murray SA. Birling MC, et al. Nat Genet. 2021 Apr;53(4):416-419. doi: 10.1038/s41588-021-00825-y. Nat Genet. 2021. PMID: 33833456 Free PMC article.
Expression of Plxdc2/TEM7R in the developing nervous system of the mouse.
Miller SF, Summerhurst K, Rünker AE, Kerjan G, Friedel RH, Chédotal A, Murphy P, Mitchell KJ. Miller SF, et al. Among authors: friedel rh. Gene Expr Patterns. 2007 Apr;7(5):635-44. doi: 10.1016/j.modgep.2006.12.002. Epub 2006 Dec 16. Gene Expr Patterns. 2007. PMID: 17280871
66 results