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Geldanamycin-induced Lyn dissociation from aberrant Hsp90-stabilized cytosolic complex is an early event in apoptotic mechanisms in B-chronic lymphocytic leukemia.
Trentin L, Frasson M, Donella-Deana A, Frezzato F, Pagano MA, Tibaldi E, Gattazzo C, Zambello R, Semenzato G, Brunati AM. Trentin L, et al. Among authors: frezzato f. Blood. 2008 Dec 1;112(12):4665-74. doi: 10.1182/blood-2008-02-139139. Epub 2008 Sep 2. Blood. 2008. PMID: 18768392 Free article.
Telomere length and telomerase levels delineate subgroups of B-cell chronic lymphocytic leukemia with different biological characteristics and clinical outcomes.
Rampazzo E, Bonaldi L, Trentin L, Visco C, Keppel S, Giunco S, Frezzato F, Facco M, Novella E, Giaretta I, Del Bianco P, Semenzato G, De Rossi A. Rampazzo E, et al. Among authors: frezzato f. Haematologica. 2012 Jan;97(1):56-63. doi: 10.3324/haematol.2011.049874. Epub 2011 Sep 20. Haematologica. 2012. PMID: 21933855 Free PMC article.
Intrinsic and extrinsic mechanisms contribute to maintain the JAK/STAT pathway aberrantly activated in T-type large granular lymphocyte leukemia.
Teramo A, Gattazzo C, Passeri F, Lico A, Tasca G, Cabrelle A, Martini V, Frezzato F, Trimarco V, Ave E, Boscaro E, Piazza F, Facco M, Trentin L, Semenzato G, Zambello R. Teramo A, et al. Among authors: frezzato f. Blood. 2013 May 9;121(19):3843-54, S1. doi: 10.1182/blood-2012-07-441378. Epub 2013 Mar 20. Blood. 2013. PMID: 23515927 Free article.
Cortactin, another player in the Lyn signaling pathway, is over-expressed and alternatively spliced in leukemic cells from patients with B-cell chronic lymphocytic leukemia.
Gattazzo C, Martini V, Frezzato F, Trimarco V, Tibaldi E, Castelli M, Facco M, Zonta F, Brunati AM, Zambello R, Semenzato G, Trentin L. Gattazzo C, et al. Among authors: frezzato f. Haematologica. 2014 Jun;99(6):1069-77. doi: 10.3324/haematol.2013.090183. Epub 2014 Feb 14. Haematologica. 2014. PMID: 24532043 Free PMC article.
Leukaemic cells from chronic lymphocytic leukaemia patients undergo apoptosis following microtubule depolymerization and Lyn inhibition by nocodazole.
Frezzato F, Trimarco V, Martini V, Gattazzo C, Ave E, Visentin A, Cabrelle A, Olivieri V, Zambello R, Facco M, Zonta F, Cristiani A, Brunati AM, Moro S, Semenzato G, Trentin L. Frezzato F, et al. Br J Haematol. 2014 Jun;165(5):659-72. doi: 10.1111/bjh.12815. Epub 2014 Mar 7. Br J Haematol. 2014. PMID: 24606526 Free article.
57 results