Fraga CAM - Search Results

1

The Use of Conformational Restriction in Medicinal Chemistry.

de Sena M Pinheiro P, Rodrigues DA, do Couto Maia R, Thota S, Fraga CAM. de Sena M Pinheiro P, et al. Among authors: fraga cam. Curr Top Med Chem. 2019;19(19):1712-1733. doi: 10.2174/1568026619666190712205025. Curr Top Med Chem. 2019. PMID: 31659944 Review.

2

Selective PGHS-2 inhibitors: a rational approach for treatment of the inflammation.

Rodrigues CR, Veloso MP, Verli H, Fraga CA, Miranda AL, Barreiro EJ. Rodrigues CR, et al. Curr Med Chem. 2002 Apr;9(8):849-67. doi: 10.2174/0929867024606786. Curr Med Chem. 2002. PMID: 11966448 Review.

3

Medicinal chemistry of N-acylhydrazones: new lead-compounds of analgesic, antiinflammatory and antithrombotic drugs.

Fraga CA, Barreiro EJ. Fraga CA, et al. Curr Med Chem. 2006;13(2):167-98. doi: 10.2174/092986706775197881. Curr Med Chem. 2006. PMID: 16472212

4

Privileged structures: a useful concept for the rational design of new lead drug candidates.

Duarte CD, Barreiro EJ, Fraga CA. Duarte CD, et al. Mini Rev Med Chem. 2007 Nov;7(11):1108-19. doi: 10.2174/138955707782331722. Mini Rev Med Chem. 2007. PMID: 18045214 Review.

5

Structural insights into IKKbeta inhibition by natural products staurosporine and quercetin.

Avila CM, Romeiro NC, Sant'Anna CM, Barreiro EJ, Fraga CA. Avila CM, et al. Bioorg Med Chem Lett. 2009 Dec 15;19(24):6907-10. doi: 10.1016/j.bmcl.2009.10.076. Epub 2009 Oct 22. Bioorg Med Chem Lett. 2009. PMID: 19896375

6

Structure-based design and biological profile of (E)-N-(4-Nitrobenzylidene)-2-naphthohydrazide, a novel small molecule inhibitor of IκB kinase-β.

Avila CM, Lopes AB, Gonçalves AS, da Silva LL, Romeiro NC, Miranda AL, Sant'Anna CM, Barreiro EJ, Fraga CA. Avila CM, et al. Eur J Med Chem. 2011 Apr;46(4):1245-53. doi: 10.1016/j.ejmech.2011.01.045. Epub 2011 Feb 3. Eur J Med Chem. 2011. PMID: 21334796

7

MAOS and medicinal chemistry: some important examples from the last years.

Nascimento-Júnior NM, Kümmerle AE, Barreiro EJ, Fraga CA. Nascimento-Júnior NM, et al. Molecules. 2011 Nov 7;16(11):9274-97. doi: 10.3390/molecules16119274. Molecules. 2011. PMID: 22064269 Free PMC article. Review.

8

Design, synthesis, and pharmacological evaluation of N-acylhydrazones and novel conformationally constrained compounds as selective and potent orally active phosphodiesterase-4 inhibitors.

Kümmerle AE, Schmitt M, Cardozo SV, Lugnier C, Villa P, Lopes AB, Romeiro NC, Justiniano H, Martins MA, Fraga CA, Bourguignon JJ, Barreiro EJ. Kümmerle AE, et al. J Med Chem. 2012 Sep 13;55(17):7525-45. doi: 10.1021/jm300514y. Epub 2012 Aug 30. J Med Chem. 2012. PMID: 22891752

9

Biotransformation of LASSBio-579 and pharmacological evaluation of p-hydroxylated metabolite a N-phenylpiperazine antipsychotic lead compound.

Gomes TF, Pompeu TE, Rodrigues DA, Noël F, Menegatti R, Andrade CH, Sabino JR, Gil ES, Dalla Costa T, Betti AH, Antonio CB, Rates SM, Fraga CA, Barreiro EJ, de Oliveira V. Gomes TF, et al. Eur J Med Chem. 2013 Apr;62:214-21. doi: 10.1016/j.ejmech.2012.08.011. Epub 2012 Aug 20. Eur J Med Chem. 2013. PMID: 23353740

10

Design, Synthesis, and Pharmacological Evaluation of Novel N-Acylhydrazone Derivatives as Potent Histone Deacetylase 6/8 Dual Inhibitors.

Rodrigues DA, Ferreira-Silva GÀ, Ferreira AC, Fernandes RA, Kwee JK, Sant'Anna CM, Ionta M, Fraga CA. Rodrigues DA, et al. J Med Chem. 2016 Jan 28;59(2):655-70. doi: 10.1021/acs.jmedchem.5b01525. Epub 2016 Jan 13. J Med Chem. 2016. PMID: 26705137

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